Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

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DOI

  • Gabriele Bellini, Newcastle University, United Kingdom
  • ,
  • Laura A. Best, Newcastle University, United Kingdom
  • ,
  • Una Brechany, Newcastle upon Tyne Hospitals NHS Foundation Trust
  • ,
  • Russell Mills, Newcastle upon Tyne Hospitals NHS Foundation Trust
  • ,
  • Nicola Pavese

Background: The role of deep brain stimulation (DBS) in the management of motor symptoms in patients with Parkinson's disease is well defined. However, it is becoming increasingly clear that DBS can either improve or worsen a number of non-motor phenomena. Objectives: We examined the published literature to better understand the effects on autonomic symptoms following DBS of the subthalamic nucleus and the globus pallidus interna. Methods: We conducted a PubMed search of studies regarding the effects of DBS on the autonomic system published from January 2001. We searched for the following terms and their combinations: Parkinson's disease, deep brain stimulation, subthalamic nucleus, globus pallidus interna, autonomic dysfunction. Results: Most studies reported in the literature focus on DBS targeting the subthalamic nucleus, with particular emphasis on favorable outcomes regarding gastrointestinal function and bladder control. However, the emergence or worsening of autonomic symptoms in subgroups of patients has also been documented. More controversial is the effect of stimulation on the cardiovascular, pulmonary, and thermo-regulatory systems as well as sexual functioning. Data regarding the influence of DBS on the autonomic system when the target is the globus pallidus interna is less forthcoming, with target selection varying according to centre and clinical indication. Conclusions: DBS appears to affect the autonomic nervous system, with varying degrees of influence, which may or may not be clinically beneficial for the patient. A better understanding of these effects could help personalize stimulation for individual patients with autonomic disorders and/or avoid autonomic symptoms in susceptible patients.

Original languageEnglish
JournalMovement Disorders Clinical Practice
Volume7
Issue4
Pages (from-to)373-382
Number of pages10
DOIs
Publication statusPublished - May 2020

    Research areas

  • autonomic system, deep brain stimulation, globus pallidus interna, Parkinson's disease, subthalamic nucleus

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