Clinical Evaluation of a New Spectral-Domain Optical Coherence Tomography-Based Biometer

Jorge L. Alió; Marina José-Martínez; Antonio Martínez-Abad; Alejandra E. Rodríguez; Francesco Versaci; Jesper Hjortdal; Joaquim Neto Murta; Ana B. Plaza-Puche; Mario Cantó-Cerdán; David P. Piñero

doi:10.3390/diagnostics14050560

Clinical Evaluation of a New Spectral-Domain Optical Coherence Tomography-Based Biometer

Jorge L. Alió, Marina José-Martínez, Antonio Martínez-Abad, Alejandra E. Rodríguez^*, Francesco Versaci, Jesper Hjortdal, Joaquim Neto Murta, Ana B. Plaza-Puche, Mario Cantó-Cerdán, David P. Piñero

^*Corresponding author for this work

Department of Clinical Medicine - Department of Ophthalmology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

The VEMoS-AXL system is a new optical biometer based on spectral domain optical coherence tomography (SD-OCT) that has been tested in terms of intrasession repeatability and compared with a swept-source optical coherence tomography biometer (SS-OCT), which is recognized as the gold standard for the performance of an agreement analysis. A biometric analysis was performed three consecutive times in 120 healthy eyes of 120 patients aged between 18 and 40 years with the SD-OCT system, and afterwards, a single measurement was obtained with the SS-OCT system. Within-subject standard deviations were 0.004 mm, 4.394 µm, and 0.017 mm for axial length (AL), central corneal thickness (CCT), and anterior chamber depth (ACD) measures obtained with the SD-OCT biometer, respectively. The agreement between devices was good for AL (limits of agreement, LoA: −0.04 to 0.03 mm) and CCT (LoA: −4.36 to 14.38 µm), whereas differences between devices were clinically relevant for ACD (LoA: 0.03 to 0.21 mm). In conclusion, the VEMoS-AXL system provides consistent measures of anatomical parameters, being most of them interchangeable with those provided by the SS-OCT-based gold standard.

Original language	English
Article number	560
Journal	Diagnostics
Volume	14
Issue	5
Number of pages	8
ISSN	2075-4418
DOIs	https://doi.org/10.3390/diagnostics14050560
Publication status	Published - Mar 2024

Keywords

anterior chamber depth
axial length
central corneal thickness
optical biometry
spectral-domain optical coherence tomography
swept-source optical coherence tomography

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title = "Clinical Evaluation of a New Spectral-Domain Optical Coherence Tomography-Based Biometer",

abstract = "The VEMoS-AXL system is a new optical biometer based on spectral domain optical coherence tomography (SD-OCT) that has been tested in terms of intrasession repeatability and compared with a swept-source optical coherence tomography biometer (SS-OCT), which is recognized as the gold standard for the performance of an agreement analysis. A biometric analysis was performed three consecutive times in 120 healthy eyes of 120 patients aged between 18 and 40 years with the SD-OCT system, and afterwards, a single measurement was obtained with the SS-OCT system. Within-subject standard deviations were 0.004 mm, 4.394 µm, and 0.017 mm for axial length (AL), central corneal thickness (CCT), and anterior chamber depth (ACD) measures obtained with the SD-OCT biometer, respectively. The agreement between devices was good for AL (limits of agreement, LoA: −0.04 to 0.03 mm) and CCT (LoA: −4.36 to 14.38 µm), whereas differences between devices were clinically relevant for ACD (LoA: 0.03 to 0.21 mm). In conclusion, the VEMoS-AXL system provides consistent measures of anatomical parameters, being most of them interchangeable with those provided by the SS-OCT-based gold standard.",

keywords = "anterior chamber depth, axial length, central corneal thickness, optical biometry, spectral-domain optical coherence tomography, swept-source optical coherence tomography",

author = "Ali{\'o}, {Jorge L.} and Marina Jos{\'e}-Mart{\'i}nez and Antonio Mart{\'i}nez-Abad and Rodr{\'i}guez, {Alejandra E.} and Francesco Versaci and Jesper Hjortdal and Murta, {Joaquim Neto} and Plaza-Puche, {Ana B.} and Mario Cant{\'o}-Cerd{\'a}n and Pi{\~n}ero, {David P.}",

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AU - Alió, Jorge L.

AU - José-Martínez, Marina

AU - Martínez-Abad, Antonio

AU - Rodríguez, Alejandra E.

AU - Versaci, Francesco

AU - Hjortdal, Jesper

AU - Murta, Joaquim Neto

AU - Plaza-Puche, Ana B.

AU - Cantó-Cerdán, Mario

AU - Piñero, David P.

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AB - The VEMoS-AXL system is a new optical biometer based on spectral domain optical coherence tomography (SD-OCT) that has been tested in terms of intrasession repeatability and compared with a swept-source optical coherence tomography biometer (SS-OCT), which is recognized as the gold standard for the performance of an agreement analysis. A biometric analysis was performed three consecutive times in 120 healthy eyes of 120 patients aged between 18 and 40 years with the SD-OCT system, and afterwards, a single measurement was obtained with the SS-OCT system. Within-subject standard deviations were 0.004 mm, 4.394 µm, and 0.017 mm for axial length (AL), central corneal thickness (CCT), and anterior chamber depth (ACD) measures obtained with the SD-OCT biometer, respectively. The agreement between devices was good for AL (limits of agreement, LoA: −0.04 to 0.03 mm) and CCT (LoA: −4.36 to 14.38 µm), whereas differences between devices were clinically relevant for ACD (LoA: 0.03 to 0.21 mm). In conclusion, the VEMoS-AXL system provides consistent measures of anatomical parameters, being most of them interchangeable with those provided by the SS-OCT-based gold standard.

KW - anterior chamber depth

KW - axial length

KW - central corneal thickness

KW - optical biometry

KW - spectral-domain optical coherence tomography

KW - swept-source optical coherence tomography

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JO - Diagnostics

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Clinical Evaluation of a New Spectral-Domain Optical Coherence Tomography-Based Biometer

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