Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries

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Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries. / Lundin, Catarina; Forestier, Erik; Klarskov Andersen, Mette; Autio, Kirsi; Barbany, Gisela; Cavelier, Lucia; Golovleva, Irina; Heim, Sverre; Heinonen, Kristiina; Hovland, Randi; Johannsson, Johann H; Kjeldsen, Eigil; Nordgren, Ann; Palmqvist, Lars; Johansson, Bertil; Nordic Society of Pediatric Hematology Oncology (NOPHO).

In: Journal of Hematology & Oncology, Vol. 7, No. 1, 2014, p. 32.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Lundin, C, Forestier, E, Klarskov Andersen, M, Autio, K, Barbany, G, Cavelier, L, Golovleva, I, Heim, S, Heinonen, K, Hovland, R, Johannsson, JH, Kjeldsen, E, Nordgren, A, Palmqvist, L, Johansson, B & Nordic Society of Pediatric Hematology Oncology (NOPHO) 2014, 'Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries', Journal of Hematology & Oncology, vol. 7, no. 1, pp. 32. https://doi.org/10.1186/1756-8722-7-32

APA

Lundin, C., Forestier, E., Klarskov Andersen, M., Autio, K., Barbany, G., Cavelier, L., ... Nordic Society of Pediatric Hematology Oncology (NOPHO) (2014). Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries. Journal of Hematology & Oncology, 7(1), 32. https://doi.org/10.1186/1756-8722-7-32

CBE

Lundin C, Forestier E, Klarskov Andersen M, Autio K, Barbany G, Cavelier L, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kjeldsen E, Nordgren A, Palmqvist L, Johansson B, Nordic Society of Pediatric Hematology Oncology (NOPHO). 2014. Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries. Journal of Hematology & Oncology. 7(1):32. https://doi.org/10.1186/1756-8722-7-32

MLA

Vancouver

Lundin C, Forestier E, Klarskov Andersen M, Autio K, Barbany G, Cavelier L et al. Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries. Journal of Hematology & Oncology. 2014;7(1):32. https://doi.org/10.1186/1756-8722-7-32

Author

Lundin, Catarina ; Forestier, Erik ; Klarskov Andersen, Mette ; Autio, Kirsi ; Barbany, Gisela ; Cavelier, Lucia ; Golovleva, Irina ; Heim, Sverre ; Heinonen, Kristiina ; Hovland, Randi ; Johannsson, Johann H ; Kjeldsen, Eigil ; Nordgren, Ann ; Palmqvist, Lars ; Johansson, Bertil ; Nordic Society of Pediatric Hematology Oncology (NOPHO). / Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries. In: Journal of Hematology & Oncology. 2014 ; Vol. 7, No. 1. pp. 32.

Bibtex

@article{67f46558de064e96b59ff3ef1d66c9e1,
title = "Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries",
abstract = "BACKGROUND: Children with Down syndrome (DS) have an increased risk for acute lymphoblastic leukemia (ALL). Although previous studies have shown that DS-ALL differs clinically and genetically from non-DS-ALL, much remains to be elucidated as regards genetic and prognostic factors in DS-ALL.METHODS: To address clinical and genetic differences between DS-ALL and non-DS-ALL and to identify prognostic factors in DS-ALL, we ascertained and reviewed all 128 pediatric DS-ALL diagnosed in the Nordic countries between 1981 and 2010. Their clinical and genetic features were compared with those of the 4,647 B-cell precursor (BCP) ALL cases diagnosed during the same time period.RESULTS: All 128 DS-ALL were BCP ALL, comprising 2.7{\%} of all such cases. The 5-year event-free survival (EFS) and overall survival (OS) were significantly (P = 0.026 and P = 0.003, respectively) worse for DS-ALL patients with white blood cell counts ≥50 × 109/l. The age distributions varied between the DS and non-DS cases, with age peaks at 2 and 3 years, respectively; none of the DS patients had infant ALL (P = 0.029). The platelet counts were lower in the DS-ALL group (P = 0.005). Abnormal karyotypes were more common in non-DS-ALL (P < 0.0001), and there was a significant difference in the modal number distribution, with only 2{\%} high hyperdiploid DS-ALL cases (P < 0.0001). The 5-year EFS and 5-year OS were significantly worse for DS-ALL (0.574 and 0.691, respectively) compared with non-DS-ALL (0.783 and 0.894, respectively) in the NOPHO ALL-1992/2000 protocols (P < 0.001).CONCLUSIONS: The present study adds further support for genetic and clinical differences between DS-ALL and non-DS-ALL.",
keywords = "Adolescent, Child, Child, Preschool, Chromosome Aberrations, Chromosome Banding, Denmark, Disease-Free Survival, Down Syndrome, Female, Finland, Humans, Iceland, In Situ Hybridization, Fluorescence, Infant, Karyotype, Karyotyping, Leukocyte Count, Male, Norway, Platelet Count, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Registries, Sweden, Treatment Outcome",
author = "Catarina Lundin and Erik Forestier and {Klarskov Andersen}, Mette and Kirsi Autio and Gisela Barbany and Lucia Cavelier and Irina Golovleva and Sverre Heim and Kristiina Heinonen and Randi Hovland and Johannsson, {Johann H} and Eigil Kjeldsen and Ann Nordgren and Lars Palmqvist and Bertil Johansson and {Nordic Society of Pediatric Hematology Oncology (NOPHO)}",
year = "2014",
doi = "10.1186/1756-8722-7-32",
language = "English",
volume = "7",
pages = "32",
journal = "Journal of Hematology & Oncology",
issn = "1756-8722",
publisher = "BioMed Central",
number = "1",

}

RIS

TY - JOUR

T1 - Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries

AU - Lundin, Catarina

AU - Forestier, Erik

AU - Klarskov Andersen, Mette

AU - Autio, Kirsi

AU - Barbany, Gisela

AU - Cavelier, Lucia

AU - Golovleva, Irina

AU - Heim, Sverre

AU - Heinonen, Kristiina

AU - Hovland, Randi

AU - Johannsson, Johann H

AU - Kjeldsen, Eigil

AU - Nordgren, Ann

AU - Palmqvist, Lars

AU - Johansson, Bertil

AU - Nordic Society of Pediatric Hematology Oncology (NOPHO)

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Children with Down syndrome (DS) have an increased risk for acute lymphoblastic leukemia (ALL). Although previous studies have shown that DS-ALL differs clinically and genetically from non-DS-ALL, much remains to be elucidated as regards genetic and prognostic factors in DS-ALL.METHODS: To address clinical and genetic differences between DS-ALL and non-DS-ALL and to identify prognostic factors in DS-ALL, we ascertained and reviewed all 128 pediatric DS-ALL diagnosed in the Nordic countries between 1981 and 2010. Their clinical and genetic features were compared with those of the 4,647 B-cell precursor (BCP) ALL cases diagnosed during the same time period.RESULTS: All 128 DS-ALL were BCP ALL, comprising 2.7% of all such cases. The 5-year event-free survival (EFS) and overall survival (OS) were significantly (P = 0.026 and P = 0.003, respectively) worse for DS-ALL patients with white blood cell counts ≥50 × 109/l. The age distributions varied between the DS and non-DS cases, with age peaks at 2 and 3 years, respectively; none of the DS patients had infant ALL (P = 0.029). The platelet counts were lower in the DS-ALL group (P = 0.005). Abnormal karyotypes were more common in non-DS-ALL (P < 0.0001), and there was a significant difference in the modal number distribution, with only 2% high hyperdiploid DS-ALL cases (P < 0.0001). The 5-year EFS and 5-year OS were significantly worse for DS-ALL (0.574 and 0.691, respectively) compared with non-DS-ALL (0.783 and 0.894, respectively) in the NOPHO ALL-1992/2000 protocols (P < 0.001).CONCLUSIONS: The present study adds further support for genetic and clinical differences between DS-ALL and non-DS-ALL.

AB - BACKGROUND: Children with Down syndrome (DS) have an increased risk for acute lymphoblastic leukemia (ALL). Although previous studies have shown that DS-ALL differs clinically and genetically from non-DS-ALL, much remains to be elucidated as regards genetic and prognostic factors in DS-ALL.METHODS: To address clinical and genetic differences between DS-ALL and non-DS-ALL and to identify prognostic factors in DS-ALL, we ascertained and reviewed all 128 pediatric DS-ALL diagnosed in the Nordic countries between 1981 and 2010. Their clinical and genetic features were compared with those of the 4,647 B-cell precursor (BCP) ALL cases diagnosed during the same time period.RESULTS: All 128 DS-ALL were BCP ALL, comprising 2.7% of all such cases. The 5-year event-free survival (EFS) and overall survival (OS) were significantly (P = 0.026 and P = 0.003, respectively) worse for DS-ALL patients with white blood cell counts ≥50 × 109/l. The age distributions varied between the DS and non-DS cases, with age peaks at 2 and 3 years, respectively; none of the DS patients had infant ALL (P = 0.029). The platelet counts were lower in the DS-ALL group (P = 0.005). Abnormal karyotypes were more common in non-DS-ALL (P < 0.0001), and there was a significant difference in the modal number distribution, with only 2% high hyperdiploid DS-ALL cases (P < 0.0001). The 5-year EFS and 5-year OS were significantly worse for DS-ALL (0.574 and 0.691, respectively) compared with non-DS-ALL (0.783 and 0.894, respectively) in the NOPHO ALL-1992/2000 protocols (P < 0.001).CONCLUSIONS: The present study adds further support for genetic and clinical differences between DS-ALL and non-DS-ALL.

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Chromosome Aberrations

KW - Chromosome Banding

KW - Denmark

KW - Disease-Free Survival

KW - Down Syndrome

KW - Female

KW - Finland

KW - Humans

KW - Iceland

KW - In Situ Hybridization, Fluorescence

KW - Infant

KW - Karyotype

KW - Karyotyping

KW - Leukocyte Count

KW - Male

KW - Norway

KW - Platelet Count

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Registries

KW - Sweden

KW - Treatment Outcome

U2 - 10.1186/1756-8722-7-32

DO - 10.1186/1756-8722-7-32

M3 - Journal article

VL - 7

SP - 32

JO - Journal of Hematology & Oncology

JF - Journal of Hematology & Oncology

SN - 1756-8722

IS - 1

ER -