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Circulating miRNAs as Biomarker in Cancer

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  • Gitte Brinch Andersen, CEA-Institut de Biologie Francois Jacob
  • ,
  • Jörg Tost, CEA-Institut de Biologie Francois Jacob

Deregulation of microRNA expression has been shown to play an important role in human malignancies. The identification of circulating-free miRNAs in biofluids a decade ago led to great enthusiasm and motivation to develop non-invasive tests based on the expression of these small non-coding RNAs. Herein, we review the progress within the field of research for identifying circulating miRNA cancer biomarkers and discuss the advantages and challenges associated with this. We also discuss the methodological and analytical variables, which may influence the final miRNA quantification and the importance of standardizing pre-analytical, analytical, and post-analytical processes in order to enable a successful translation of the results from basic research into the clinics.

Original languageEnglish
Title of host publicationTumor Liquid Biopsies
Number of pages22
Publication year1 Jan 2020
Publication statusPublished - 1 Jan 2020
SeriesRecent Results in Cancer Research

    Research areas

  • Biofluids, Biomarker, Cancer, Diagnosis, miRNA, Precision medicine, Prognosis

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