Circulating miRNAs as Biomarker in Cancer

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  • Gitte Brinch Andersen, CEA-Institut de Biologie Francois Jacob
  • ,
  • Jörg Tost, CEA-Institut de Biologie Francois Jacob

Deregulation of microRNA expression has been shown to play an important role in human malignancies. The identification of circulating-free miRNAs in biofluids a decade ago led to great enthusiasm and motivation to develop non-invasive tests based on the expression of these small non-coding RNAs. Herein, we review the progress within the field of research for identifying circulating miRNA cancer biomarkers and discuss the advantages and challenges associated with this. We also discuss the methodological and analytical variables, which may influence the final miRNA quantification and the importance of standardizing pre-analytical, analytical, and post-analytical processes in order to enable a successful translation of the results from basic research into the clinics.

Original languageEnglish
Title of host publicationTumor Liquid Biopsies
Number of pages22
PublisherSpringer
Publication year1 Jan 2020
Pages277-298
DOIs
Publication statusPublished - 1 Jan 2020
SeriesRecent Results in Cancer Research
Volume215
ISSN0080-0015

    Research areas

  • Biofluids, Biomarker, Cancer, Diagnosis, miRNA, Precision medicine, Prognosis

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