Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Manon Cairat, International Agency for Research on Cancer
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  • Sabina Rinaldi, International Agency for Research on Cancer
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  • Anne Sophie Navionis, International Agency for Research on Cancer
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  • Isabelle Romieu, Instituto Nacional de Salud Publica
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  • Carine Biessy, International Agency for Research on Cancer
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  • Vivian Viallon, International Agency for Research on Cancer
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  • Anja Olsen
  • Anne Tjønneland, Danish Cancer Society, University of Copenhagen
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  • Agnès Fournier, Universite Paris-Saclay
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  • Gianluca Severi, Universite Paris-Saclay, University of Florence
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  • Marina Kvaskoff, Universite Paris-Saclay
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  • Renée T. Fortner, German Cancer Research Center
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  • Rudolf Kaaks, German Cancer Research Center
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  • Krasimira Aleksandrova, Leibniz Institute for Prevention Research and Epidemiology, University of Bremen
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  • Matthias B. Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, University of Potsdam
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  • Giovanna Masala, Institute for the Study and Prevention of Cancer
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  • Rosario Tumino, Hyblean Association for Epidemiological Research AIRE –ONLUS
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  • Sabina Sieri, IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
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  • Chiara Grasso, University of Turin
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  • Amalia Mattiello, University of Naples Federico II
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  • Inger T. Gram, UiT The Arctic University of Norway
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  • Karina Standahl Olsen, UiT The Arctic University of Norway
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  • Antonio Agudo, Institute Catala Oncologia, Bellvitge Biomedical Research Institute
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  • Pilar Amiano Etxezarreta, Ministry of Health of the Basque Government, Instituto de Investigación Sanitaria Biodonostia, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)
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  • Maria Jose Sánchez, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada
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  • Carmen Santiuste, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Council
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  • Aurelio Barricarte, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Navarra Public Health Institute, Navarra Institute for Health Research
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  • Evelyn Monninkhof, Utrecht University
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  • Anouk E. Hiensch, Utrecht University
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  • David Muller, Imperial College London
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  • Melissa A. Merritt, Imperial College London, University of Hawaii at Manoa
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  • Ruth C. Travis, University of Oxford
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  • Elisabete Weiderpass, International Agency for Research on Cancer
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  • Marc J. Gunter, International Agency for Research on Cancer
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  • Laure Dossus, International Agency for Research on Cancer

Background: Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. Methods: Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. Results: Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77–1.03), OR= 0.88 (0.76–1.01) and OR= 0.87 (0.75–1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05–1.29), OR= 1.11 (1.01–1.23), OR= 1.10 (0.99–1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68–1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66–0.97), CRP: OR = 0.85 (0.72–1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96–1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89–1.16), CRP: OR = 1.04 (0.92–1.16)]. Conclusions: Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.

Original languageEnglish
Article number118
JournalBMC Medicine
Volume20
Issue1
Number of pages14
ISSN1741-7015
DOIs
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

    Research areas

  • Anthropometry, Biomarkers, Breast cancer, Inflammation, Menopausal status

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