Circular RNAs in cancer: opportunities and challenges in the field

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Documents

  • onc2017361

    Final published version, 1 MB, PDF document

DOI

Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a steadily increasing pace. The list of endogenous circRNAs involved in cancer continues to grow; however, the functional relevance of the vast majority is yet to be discovered. In general, circRNAs are exceptionally stable molecules and some have been shown to function as efficient microRNA sponges with gene-regulatory potential. Many circRNAs are highly conserved and have tissue-specific expression patterns, which often do not correlate well with host gene expression. Here we review the current knowledge on circRNAs in relation to their implications in tumorigenesis as well as their potential as diagnostic and prognostic biomarkers and as possible therapeutic targets in future personalized medicine. Finally, we discuss future directions for circRNA cancer research and current caveats, which must be addressed to facilitate the translation of basic circRNA research into clinical use.Oncogene advance online publication, 9 October 2017; doi:10.1038/onc.2017.361.

Original languageEnglish
JournalOncogene
Volume37
Pages (from-to)555–565
ISSN0950-9232
DOIs
Publication statusPublished - 1 Feb 2018

    Research areas

  • Journal Article, Review

See relations at Aarhus University Citationformats

Download statistics

No data available

ID: 119430003