Aarhus University Seal / Aarhus Universitets segl

Circular RNAs: Identification, biogenesis and function

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Circular RNAs are a novel class of non-coding RNA characterized by the presence of a covalent bond linking the 3' and 5' ends generated by backsplicing. Circular RNAs are widely expressed in a tissue and developmental-stage specific pattern and a subset displays conservation across species. Functional circRNAs have been shown to act as cytoplasmic microRNA sponges and RNA-binding protein sequestering agents as well as nuclear transcriptional regulators, illustrating the relevance of circular RNAs as participants in the regulatory networks governing gene expression. Here, we review the features that characterize circular RNAs, discuss putative circular RNA biogenesis pathways as well as review the uncovered functions of circular RNAs.

Original languageEnglish
JournalBBA General Subjects
Volume1859
Issue1
Pages (from-to)163-168
Number of pages6
ISSN0304-4165
DOIs
Publication statusPublished - 2016

See relations at Aarhus University Citationformats

ID: 95392752