Chronic restraint stress increases the protein expression of VEGF and its receptor VEGFR-2 in the prefrontal cortex

TY - JOUR

T1 - Chronic restraint stress increases the protein expression of VEGF and its receptor VEGFR-2 in the prefrontal cortex

AU - Elfving, Betina

AU - Jakobsen, Jakob Lerche

AU - Madsen, Jens Christian Bredahl

AU - Wegener, Gregers

AU - Müller, Heidi Kaastrup

N1 - Copyright © 2015 Wiley Periodicals, Inc., a Wiley company.

PY - 2015/2/5

Y1 - 2015/2/5

N2 - In the present study the central and peripheral regulation of VEGF, its cognate receptors, and regulators were examined after acute and chronic restraint stress in rats. After chronic restraint stress (6 hours per day for 21 days) the protein levels of VEGF (175%±24%) and its receptor VEGFR-2 (169%±17%) increased significantly in the prefrontal cortex (A&B). mRNA levels of VEGFR-2 (132%±11%) were also significantly increased (D). In the hippocampus no significant changes were observed at the mRNA or protein levels. In serum there was a tendency towards increased VEGF protein expression after both acute and chronic restraint stress (C).

AB - In the present study the central and peripheral regulation of VEGF, its cognate receptors, and regulators were examined after acute and chronic restraint stress in rats. After chronic restraint stress (6 hours per day for 21 days) the protein levels of VEGF (175%±24%) and its receptor VEGFR-2 (169%±17%) increased significantly in the prefrontal cortex (A&B). mRNA levels of VEGFR-2 (132%±11%) were also significantly increased (D). In the hippocampus no significant changes were observed at the mRNA or protein levels. In serum there was a tendency towards increased VEGF protein expression after both acute and chronic restraint stress (C).

U2 - 10.1002/syn.21808

DO - 10.1002/syn.21808

M3 - Journal article

C2 - 25655083

SN - 0887-4476

JO - Synapse

JF - Synapse

ER -