Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • A Dudele
  • K S Hougaard, Department of Public Health, Section for Occupational and Environmental Health, University of Copenhagen, Copenhagen, Denmark.
  • ,
  • M Kjølby
  • M Hokland
  • G Winther
  • B Elfving
  • G Wegener
  • A L Nielsen
  • A Larsen
  • ,
  • M K Nøhr, Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
  • ,
  • S B Pedersen, Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
  • ,
  • T Wang
  • S Lund

BACKGROUND/OBJECTIVES: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.

METHODS: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.

RESULTS: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.

CONCLUSIONS: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.International Journal of Obesity advance online publication, 4 July 2017; doi:10.1038/ijo.2017.136.

Original languageEnglish
JournalInternational Journal of Obesity
Volume41
Issue9
Pages (from-to)1420-1426
Number of pages7
ISSN0307-0565
DOIs
Publication statusPublished - 7 Jun 2017

    Research areas

  • Journal Article

See relations at Aarhus University Citationformats

ID: 116149459