Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

A Dudele; K S Hougaard; M Kjølby; M Hokland; G Winther; B Elfving; G Wegener; A L Nielsen; A Larsen; M K Nøhr; S B Pedersen; T Wang; S Lund

doi:10.1038/ijo.2017.136

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

A Dudele, K S Hougaard, M Kjølby, M Hokland, G Winther, B Elfving, G Wegener, A L Nielsen, A Larsen, M K Nøhr, S B Pedersen, T Wang, S Lund

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

Original language	English
Journal	International Journal of Obesity
Volume	41
Issue	9
Pages (from-to)	1420-1426
Number of pages	7
ISSN	0307-0565
DOIs	https://doi.org/10.1038/ijo.2017.136
Publication status	Published - 7 Jun 2017

Keywords

Journal Article

Access to Document

10.1038/ijo.2017.136

Cite this

Dudele, A., Hougaard, K. S., Kjølby, M., Hokland, M., Winther, G., Elfving, B., Wegener, G., Nielsen, A. L., Larsen, A., Nøhr, M. K., Pedersen, S. B., Wang, T., & Lund, S. (2017). Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. International Journal of Obesity, 41(9), 1420-1426. https://doi.org/10.1038/ijo.2017.136

@article{28bb1f9324824f1da79af1debd42dc81,

title = "Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner",

abstract = "Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.",

keywords = "Journal Article",

author = "A Dudele and Hougaard, {K S} and M Kj{\o}lby and M Hokland and G Winther and B Elfving and G Wegener and Nielsen, {A L} and A Larsen and N{\o}hr, {M K} and Pedersen, {S B} and T Wang and S Lund",

year = "2017",

month = jun,

day = "7",

doi = "10.1038/ijo.2017.136",

language = "English",

volume = "41",

pages = "1420--1426",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Springer Nature",

number = "9",

}

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. / Dudele, A; Hougaard, K S; Kjølby, M et al.
In: International Journal of Obesity, Vol. 41, No. 9, 07.06.2017, p. 1420-1426.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

AU - Dudele, A

AU - Hougaard, K S

AU - Kjølby, M

AU - Hokland, M

AU - Winther, G

AU - Elfving, B

AU - Wegener, G

AU - Nielsen, A L

AU - Larsen, A

AU - Nøhr, M K

AU - Pedersen, S B

AU - Wang, T

AU - Lund, S

PY - 2017/6/7

Y1 - 2017/6/7

N2 - Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

AB - Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85028863391&partnerID=8YFLogxK

U2 - 10.1038/ijo.2017.136

DO - 10.1038/ijo.2017.136

M3 - Journal article

C2 - 28588305

SN - 0307-0565

VL - 41

SP - 1420

EP - 1426

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 9

ER -

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this