Cholinergic Imaging and Dementia

TY - CHAP

T1 - Cholinergic Imaging and Dementia

AU - Okkels, Niels

AU - Horsager, Jacob

AU - Pavese, Nicola

AU - Brooks, David J.

AU - Borghammer, Per

N1 - Publisher Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - There is evidence of early pathological changes in cholinergic neurons of patients with Alzheimer’s disease and Lewy body disease. This makes cholinergic molecular imaging one of the most important tools for studying prodromal and preclinical disease states of dementia. Various tracers have been developed for visualizing the cholinergic system. They have demonstrated profound cholinergic dysfunction in the cholinergic system of manifest dementia. Cholinergic dysfunction is also evident in prodromal stages of dementia. Evidence points to pathology first arising in the cholinergic axons and cell bodies of the basal forebrain in Alzheimer’s disease dementia and some cases of Parkinson’s disease dementia and dementia with Lewy bodies. In another group of patients with Lewy body disease, the early pathology involves peripheral cholinergic neurons of the parasympathetic nervous system. Cholinergic molecular imaging is an important tool contributing to the search of where and when the pathological processes leading to dementia begins.

AB - There is evidence of early pathological changes in cholinergic neurons of patients with Alzheimer’s disease and Lewy body disease. This makes cholinergic molecular imaging one of the most important tools for studying prodromal and preclinical disease states of dementia. Various tracers have been developed for visualizing the cholinergic system. They have demonstrated profound cholinergic dysfunction in the cholinergic system of manifest dementia. Cholinergic dysfunction is also evident in prodromal stages of dementia. Evidence points to pathology first arising in the cholinergic axons and cell bodies of the basal forebrain in Alzheimer’s disease dementia and some cases of Parkinson’s disease dementia and dementia with Lewy bodies. In another group of patients with Lewy body disease, the early pathology involves peripheral cholinergic neurons of the parasympathetic nervous system. Cholinergic molecular imaging is an important tool contributing to the search of where and when the pathological processes leading to dementia begins.

KW - Alzheimer’s disease

KW - Cholinergic neurons

KW - Dementia

KW - Dementia with Lewy bodies

KW - Lewy body disease

KW - Parkinson’s disease

KW - Parkinson’s disease dementia

KW - PET-CT

UR - http://www.scopus.com/inward/record.url?scp=85205155576&partnerID=8YFLogxK

U2 - 10.1007/978-3-031-35098-6_8

DO - 10.1007/978-3-031-35098-6_8

M3 - Book chapter

AN - SCOPUS:85205155576

SN - 9783031350979

SP - 127

EP - 144

BT - Molecular Imaging of Neurodegenerative Disorders

PB - Springer International Publishing

ER -