Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth

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  • Interdisciplinary Nanoscience Center
  • Department of Molecular Biology
  • Department of Molecular Biology
Microstructured 20 μm thick polymer filaments used as nerve implants were loaded with chitosan/siRNA nanoparticles to promote nerve regeneration and ensure local delivery of nanotherapeutics. The stable nanoparticles were rapidly internalized by cells and did not affect cell viability. Target mRNA was successfully reduced by 65-75% and neurite outgrowth was enhanced even in an inhibitory environment. This work, thus, supports the application of nanobiofunctionalized implants as a novel approach for spinal cord and nerve repair.
Original languageEnglish
JournalNano Letters
Volume10
Issue10
Pages (from-to)3933-9
Number of pages7
ISSN1530-6984
DOIs
Publication statusPublished - 13 Oct 2010

    Research areas

  • Animals, Cell Line, Chitosan, Nanoparticles, Nerve Regeneration, Neurites, Neurons, Prostheses and Implants, RNA, Small Interfering, Transfection, rhoA GTP-Binding Protein

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