Childhood infections and subsequent school achievement among 598,553 Danish children

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Childhood infections and subsequent school achievement among 598,553 Danish children. / Köhler-Forsberg, Ole; Sørensen, Holger; Nordentoft, Merete; McGrath, John Joseph; Benros, Michael Eriksen; Petersen, Liselotte.

In: Pediatric Infectious Disease Journal, Vol. 37, No. 8, 08.2018, p. 731–737.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Köhler-Forsberg, O, Sørensen, H, Nordentoft, M, McGrath, JJ, Benros, ME & Petersen, L 2018, 'Childhood infections and subsequent school achievement among 598,553 Danish children', Pediatric Infectious Disease Journal, vol. 37, no. 8, pp. 731–737. https://doi.org/10.1097/INF.0000000000001869

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Author

Köhler-Forsberg, Ole ; Sørensen, Holger ; Nordentoft, Merete ; McGrath, John Joseph ; Benros, Michael Eriksen ; Petersen, Liselotte. / Childhood infections and subsequent school achievement among 598,553 Danish children. In: Pediatric Infectious Disease Journal. 2018 ; Vol. 37, No. 8. pp. 731–737.

Bibtex

@article{4c5fc68ab01840e982f1268b4fa4957d,
title = "Childhood infections and subsequent school achievement among 598,553 Danish children",
abstract = "BACKGROUND: Hospitalizations for infections have been associated with subsequent decreased cognitive ability, but it is uncertain if childhood infections influence subsequent scholastic achievement (SA). We aimed to estimate the association between infections during childhood and SA. METHODS: Nationwide prospective cohort study including 598,553 children born in Denmark between 1987 and 1997 and their parents. Exposures were hospitalization for infections and treatment with anti-infective agents. Outcomes were completion of ninth grade and ninth grade test scores. Data were analyzed with logistic and linear regression analysis techniques and adjusted for any mental disorder, birthweight, Apgar score, malformations at birth, chronic somatic diseases, first-born child, parental educational level and parental mental disorders. RESULTS: Hospitalization with infections was linked to lower completion of ninth grade with an odds ratio of 0.82 (95{\%} confidence interval: 0.79-0.85) compared with children without prior hospitalizations for infections. Dose-response relationships were observed with respect to number of hospital contacts for infections and a shorter time since last hospitalization (all P < 0.001). Among those who completed the ninth grade test score, we found a dose-response and time-since relationship between number of prior severe infections and subsequent lower grade scores (P < 0.001). Treatment of nonsevere infections with anti-infective agents did not predict lower completion of ninth grade but was associated with lower grade scores (P < 0.001). CONCLUSIONS: Infections, particularly those requiring hospitalizations, were associated with subsequent affected cognitive ability as indicated by lower SA. These findings might also be explained by missed school days or socioeconomic factors associated with the susceptibility of acquiring infections.",
keywords = "Academic Success, Adolescent, Birth Weight, Child, Cohort Studies, Communicable Diseases/drug therapy, Denmark/epidemiology, Female, Hospitalization/statistics & numerical data, Humans, Linear Models, Male, Prospective Studies, Registries, Risk Factors, Schools/statistics & numerical data, Socioeconomic Factors",
author = "Ole K{\"o}hler-Forsberg and Holger S{\o}rensen and Merete Nordentoft and McGrath, {John Joseph} and Benros, {Michael Eriksen} and Liselotte Petersen",
year = "2018",
month = "8",
doi = "10.1097/INF.0000000000001869",
language = "English",
volume = "37",
pages = "731–737",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams & Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Childhood infections and subsequent school achievement among 598,553 Danish children

AU - Köhler-Forsberg, Ole

AU - Sørensen, Holger

AU - Nordentoft, Merete

AU - McGrath, John Joseph

AU - Benros, Michael Eriksen

AU - Petersen, Liselotte

PY - 2018/8

Y1 - 2018/8

N2 - BACKGROUND: Hospitalizations for infections have been associated with subsequent decreased cognitive ability, but it is uncertain if childhood infections influence subsequent scholastic achievement (SA). We aimed to estimate the association between infections during childhood and SA. METHODS: Nationwide prospective cohort study including 598,553 children born in Denmark between 1987 and 1997 and their parents. Exposures were hospitalization for infections and treatment with anti-infective agents. Outcomes were completion of ninth grade and ninth grade test scores. Data were analyzed with logistic and linear regression analysis techniques and adjusted for any mental disorder, birthweight, Apgar score, malformations at birth, chronic somatic diseases, first-born child, parental educational level and parental mental disorders. RESULTS: Hospitalization with infections was linked to lower completion of ninth grade with an odds ratio of 0.82 (95% confidence interval: 0.79-0.85) compared with children without prior hospitalizations for infections. Dose-response relationships were observed with respect to number of hospital contacts for infections and a shorter time since last hospitalization (all P < 0.001). Among those who completed the ninth grade test score, we found a dose-response and time-since relationship between number of prior severe infections and subsequent lower grade scores (P < 0.001). Treatment of nonsevere infections with anti-infective agents did not predict lower completion of ninth grade but was associated with lower grade scores (P < 0.001). CONCLUSIONS: Infections, particularly those requiring hospitalizations, were associated with subsequent affected cognitive ability as indicated by lower SA. These findings might also be explained by missed school days or socioeconomic factors associated with the susceptibility of acquiring infections.

AB - BACKGROUND: Hospitalizations for infections have been associated with subsequent decreased cognitive ability, but it is uncertain if childhood infections influence subsequent scholastic achievement (SA). We aimed to estimate the association between infections during childhood and SA. METHODS: Nationwide prospective cohort study including 598,553 children born in Denmark between 1987 and 1997 and their parents. Exposures were hospitalization for infections and treatment with anti-infective agents. Outcomes were completion of ninth grade and ninth grade test scores. Data were analyzed with logistic and linear regression analysis techniques and adjusted for any mental disorder, birthweight, Apgar score, malformations at birth, chronic somatic diseases, first-born child, parental educational level and parental mental disorders. RESULTS: Hospitalization with infections was linked to lower completion of ninth grade with an odds ratio of 0.82 (95% confidence interval: 0.79-0.85) compared with children without prior hospitalizations for infections. Dose-response relationships were observed with respect to number of hospital contacts for infections and a shorter time since last hospitalization (all P < 0.001). Among those who completed the ninth grade test score, we found a dose-response and time-since relationship between number of prior severe infections and subsequent lower grade scores (P < 0.001). Treatment of nonsevere infections with anti-infective agents did not predict lower completion of ninth grade but was associated with lower grade scores (P < 0.001). CONCLUSIONS: Infections, particularly those requiring hospitalizations, were associated with subsequent affected cognitive ability as indicated by lower SA. These findings might also be explained by missed school days or socioeconomic factors associated with the susceptibility of acquiring infections.

KW - Academic Success

KW - Adolescent

KW - Birth Weight

KW - Child

KW - Cohort Studies

KW - Communicable Diseases/drug therapy

KW - Denmark/epidemiology

KW - Female

KW - Hospitalization/statistics & numerical data

KW - Humans

KW - Linear Models

KW - Male

KW - Prospective Studies

KW - Registries

KW - Risk Factors

KW - Schools/statistics & numerical data

KW - Socioeconomic Factors

UR - http://www.scopus.com/inward/record.url?scp=85064853098&partnerID=8YFLogxK

U2 - 10.1097/INF.0000000000001869

DO - 10.1097/INF.0000000000001869

M3 - Journal article

C2 - 29278614

VL - 37

SP - 731

EP - 737

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 8

ER -