Characterization of dopaminergic dysfunction in familial progressive supranuclear palsy: An 18F-dopa PET study

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  • Y. F. Tai, Hammersmith Hospital
  • ,
  • R. L. Ahsan, Hammersmith Hospital
  • ,
  • J. G. De Yébenes, Universidad Autonoma de Madrid
  • ,
  • N. Pavese
  • D. J. Brooks
  • P. Piccini, Hammersmith Hospital

We analyzed 18F-dopa PET data from 11 members of kindreds with familial progressive supranuclear palsy (PSP) to characterize their cerebral dopaminergic dysfunction. Three clinically-affected PSP patients showed reduced 18F-dopa uptake in the striatum, orbitofrontal cortex and amygdala. One asymptomatic subject exhibited progressive putamen dopaminergic dysfunction. 60% of subjects with abnormal 18F-dopa scans developed PSP subsequently. This is the first in vivo documentation of cortical dopaminergic deficiency in PSP. Reduced striatal 18F-dopa uptake in susceptible relatives may predict later clinical disease.

Original languageEnglish
JournalJournal of Neural Transmission
Volume114
Issue3
Pages (from-to)337-340
Number of pages4
ISSN0300-9564
DOIs
Publication statusPublished - 1 Mar 2007
Externally publishedYes

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