Characterization of a "TRAMP-like" co-factor of the human RNA exosome

Research output: Contribution to conferenceConference abstract for conferenceResearch

Standard

Characterization of a "TRAMP-like" co-factor of the human RNA exosome. / Christensen, Marianne Skovgaard; Kristiansen, Maiken Søndergaard; Lubas, Michal Szymon; Jensen, Torben Heick.

2010. Abstract from MoMeD Summer School 2010, Lund, Sweden.

Research output: Contribution to conferenceConference abstract for conferenceResearch

Harvard

Christensen, MS, Kristiansen, MS, Lubas, MS & Jensen, TH 2010, 'Characterization of a "TRAMP-like" co-factor of the human RNA exosome', Lund, Sweden, 01/06/2010 - 02/06/2010, .

APA

Christensen, M. S., Kristiansen, M. S., Lubas, M. S., & Jensen, T. H. (2010). Characterization of a "TRAMP-like" co-factor of the human RNA exosome. Abstract from MoMeD Summer School 2010, Lund, Sweden.

CBE

Christensen MS, Kristiansen MS, Lubas MS, Jensen TH. 2010. Characterization of a "TRAMP-like" co-factor of the human RNA exosome. Abstract from MoMeD Summer School 2010, Lund, Sweden.

MLA

Christensen, Marianne Skovgaard et al. Characterization of a "TRAMP-like" co-factor of the human RNA exosome. 2010.

Vancouver

Christensen MS, Kristiansen MS, Lubas MS, Jensen TH. Characterization of a "TRAMP-like" co-factor of the human RNA exosome. 2010. Abstract from MoMeD Summer School 2010, Lund, Sweden.

Author

Christensen, Marianne Skovgaard ; Kristiansen, Maiken Søndergaard ; Lubas, Michal Szymon ; Jensen, Torben Heick. / Characterization of a "TRAMP-like" co-factor of the human RNA exosome. Abstract from MoMeD Summer School 2010, Lund, Sweden.

Bibtex

@conference{00177190023a11e083f5000ea68e967b,
title = "Characterization of a {"}TRAMP-like{"} co-factor of the human RNA exosome",
abstract = "Genome-wide studies in yeast, plants and humans have revealed numerous new transcripts in what was previously thought to be silent DNA or junk DNA. One class of non-coding transcript discovered recently is the PROMoter uPstream Transcripts (PROMPTs), which is only seen upon depletion of the RNA exosome, the major 3’-5’ exonuclease complex in human cells. PROMPTs have a lot in common with the yeast Cryptic Unstable Transcripts (CUTs), which are degraded by the concerted effort of the exosome, and its co-factor complex TRAMP (Trf4p/Air1p/Mtr4p).We have identified human proteins with functional similarities to components of the yeast TRAMP complex, and show that these are involved in the degradation of PROMPTs. While, these proteins form transient complexes with the exosome, our preliminary results also indicate that complex formation can occur directly with catalytic components of the exosome, serving to degrade PROMPTs in a core exosome independent manner.",
author = "Christensen, {Marianne Skovgaard} and Kristiansen, {Maiken S{\o}ndergaard} and Lubas, {Michal Szymon} and Jensen, {Torben Heick}",
year = "2010",
language = "English",
note = "null ; Conference date: 01-06-2010 Through 02-06-2010",

}

RIS

TY - ABST

T1 - Characterization of a "TRAMP-like" co-factor of the human RNA exosome

AU - Christensen, Marianne Skovgaard

AU - Kristiansen, Maiken Søndergaard

AU - Lubas, Michal Szymon

AU - Jensen, Torben Heick

PY - 2010

Y1 - 2010

N2 - Genome-wide studies in yeast, plants and humans have revealed numerous new transcripts in what was previously thought to be silent DNA or junk DNA. One class of non-coding transcript discovered recently is the PROMoter uPstream Transcripts (PROMPTs), which is only seen upon depletion of the RNA exosome, the major 3’-5’ exonuclease complex in human cells. PROMPTs have a lot in common with the yeast Cryptic Unstable Transcripts (CUTs), which are degraded by the concerted effort of the exosome, and its co-factor complex TRAMP (Trf4p/Air1p/Mtr4p).We have identified human proteins with functional similarities to components of the yeast TRAMP complex, and show that these are involved in the degradation of PROMPTs. While, these proteins form transient complexes with the exosome, our preliminary results also indicate that complex formation can occur directly with catalytic components of the exosome, serving to degrade PROMPTs in a core exosome independent manner.

AB - Genome-wide studies in yeast, plants and humans have revealed numerous new transcripts in what was previously thought to be silent DNA or junk DNA. One class of non-coding transcript discovered recently is the PROMoter uPstream Transcripts (PROMPTs), which is only seen upon depletion of the RNA exosome, the major 3’-5’ exonuclease complex in human cells. PROMPTs have a lot in common with the yeast Cryptic Unstable Transcripts (CUTs), which are degraded by the concerted effort of the exosome, and its co-factor complex TRAMP (Trf4p/Air1p/Mtr4p).We have identified human proteins with functional similarities to components of the yeast TRAMP complex, and show that these are involved in the degradation of PROMPTs. While, these proteins form transient complexes with the exosome, our preliminary results also indicate that complex formation can occur directly with catalytic components of the exosome, serving to degrade PROMPTs in a core exosome independent manner.

M3 - Conference abstract for conference

ER -