Changing epidemiology of the respiratory bacteriology of patients with cystic fibrosis–data from the European cystic fibrosis society patient registry

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Elpis Hatziagorou, Aristotle University of Thessaloniki
  • ,
  • Annalisa Orenti, University of Milan
  • ,
  • Pavel Drevinek, Motol University Hospital
  • ,
  • Nataliya Kashirskaya, Russian Academy of Medical Sciences
  • ,
  • Meir Mei-Zahav, Tel Aviv University
  • ,
  • Kris De Boeck, KU Leuven
  • ,
  • on behalf of the ECFSPR

Background: Monitoring changes in the epidemiology of cystic fibrosis (CF) pathogens is essential for clinical research, quality improvement, and clinical management. Methods: We analyzed data reported to the European Cystic Fibrosis Society Patient Registry (ECFSPR) from 2011 to 2016 to determine the overall and the age-specific annual prevalence and incidence of selected CF pathogens and their trends during these years. The ECFSPR collects data on three chronic infections: Pseudomonas aeruginosa (PsA), Burkholderia cepacia complex Species (BCC) and Staphylococcus aureus (SA), as well as on the occurrence of non-tuberculous mycobacteria (NTM) and Stenotrophomonas maltophilia (SM). The same analyses were performed for different country groups, according to their gross national income (GNI). Results: The pathogens with the highest prevalence were SA and PsA, with prevalence, in 2016, equal to 38.3% and 29.8% respectively, followed by SM (8.1%). The pathogens with the lowest prevalence were NTM (3.3%) and BCC (3.1%). The overall prevalence and incidence significantly decreased for PsA; they also decreased for BCC, while they increased significantly for SA. The overall prevalence of NTM and SM increased significantly. The most considerable prevalence changes were observed for PsA, which decreased across all income country groups and all age strata (with the exception of 0–1 years) The prevalence and incidence of pathogens differed significantly according to GNI. Conclusions: The epidemiology of CF pathogens in Europe has changed; epidemiologic data differ significantly among countries with different socio-economic status. The causes of these observations are multifactorial and include improvements in clinical care and infection control.

Original languageEnglish
JournalJournal of Cystic Fibrosis
Volume19
Issue3
Pages (from-to)376-383
Number of pages8
ISSN1569-1993
DOIs
Publication statusPublished - May 2020

    Research areas

  • Cystic fibrosis, Epidemiology, Pseudomonas aeruginosa, Registry, Staphylococcus aureus

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