Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space

Petra M. Wise; Paolo Neviani; Stefan Riwaldt; Thomas J. Corydon; Markus Wehland; Markus Braun; Marcus Krüger; Manfred Infanger; Daniela Grimm

doi:10.3390/ijms222312841

Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space

Petra M. Wise, Paolo Neviani, Stefan Riwaldt, Thomas J. Corydon, Markus Wehland, Markus Braun, Marcus Krüger, Manfred Infanger, Daniela Grimm^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

12 Citations (Scopus)

Abstract

As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, research-ing the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Station, we are now taking advantage of the newest technological opportunities to gain more insight into the changes in cell–cell communication of these cells. Analyzing the exosomal microRNA composition after several days of microgravity might elucidate some of the proteomic changes we have reported earlier. An array scan of a total of 754 miRNA targets revealed more than 100 differentially expressed miRNAs in our samples, many of which have been implicated in thyroid disease in other studies.

Original language	English
Article number	12841
Journal	International Journal of Molecular Sciences
Volume	22
Issue	23
Number of pages	24
ISSN	1661-6596
DOIs	https://doi.org/10.3390/ijms222312841
Publication status	Published - Nov 2021

Keywords

Cell culture
Exosomes
Microgravity
MiRNA
Spaceflight
Thyroid cancer

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10.3390/ijms222312841Licence: CC BY

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@article{eb2ebd0cfaf44bd78f62169f893ef21a,

title = "Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space",

abstract = "As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, research-ing the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Station, we are now taking advantage of the newest technological opportunities to gain more insight into the changes in cell–cell communication of these cells. Analyzing the exosomal microRNA composition after several days of microgravity might elucidate some of the proteomic changes we have reported earlier. An array scan of a total of 754 miRNA targets revealed more than 100 differentially expressed miRNAs in our samples, many of which have been implicated in thyroid disease in other studies.",

keywords = "Cell culture, Exosomes, Microgravity, MiRNA, Spaceflight, Thyroid cancer",

author = "Wise, {Petra M.} and Paolo Neviani and Stefan Riwaldt and Corydon, {Thomas J.} and Markus Wehland and Markus Braun and Marcus Kr{\"u}ger and Manfred Infanger and Daniela Grimm",

year = "2021",

month = nov,

doi = "10.3390/ijms222312841",

language = "English",

volume = "22",

journal = "International Journal of Molecular Sciences ",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "23",

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Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space. / Wise, Petra M.; Neviani, Paolo; Riwaldt, Stefan et al.
In: International Journal of Molecular Sciences , Vol. 22, No. 23, 12841, 11.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space

AU - Wise, Petra M.

AU - Neviani, Paolo

AU - Riwaldt, Stefan

AU - Corydon, Thomas J.

AU - Wehland, Markus

AU - Braun, Markus

AU - Krüger, Marcus

AU - Infanger, Manfred

AU - Grimm, Daniela

PY - 2021/11

Y1 - 2021/11

N2 - As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, research-ing the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Station, we are now taking advantage of the newest technological opportunities to gain more insight into the changes in cell–cell communication of these cells. Analyzing the exosomal microRNA composition after several days of microgravity might elucidate some of the proteomic changes we have reported earlier. An array scan of a total of 754 miRNA targets revealed more than 100 differentially expressed miRNAs in our samples, many of which have been implicated in thyroid disease in other studies.

AB - As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, research-ing the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Station, we are now taking advantage of the newest technological opportunities to gain more insight into the changes in cell–cell communication of these cells. Analyzing the exosomal microRNA composition after several days of microgravity might elucidate some of the proteomic changes we have reported earlier. An array scan of a total of 754 miRNA targets revealed more than 100 differentially expressed miRNAs in our samples, many of which have been implicated in thyroid disease in other studies.

KW - Cell culture

KW - Exosomes

KW - Microgravity

KW - MiRNA

KW - Spaceflight

KW - Thyroid cancer

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U2 - 10.3390/ijms222312841

DO - 10.3390/ijms222312841

M3 - Journal article

C2 - 34884646

AN - SCOPUS:85119930490

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 23

M1 - 12841

ER -

Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space

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