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Cell mimicry as a bottom-up strategy for hierarchical engineering of nature-inspired entities

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Artificial biology is an emerging concept that aims to design and engineer the structure and function of natural cells, organelles, or biomolecules with a combination of biological and abiotic building blocks. Cell mimicry focuses on concepts that have the potential to be integrated with mammalian cells and tissue. In this feature article, we will emphasize the advancements in the past 3–4 years (2017-present) that are dedicated to artificial enzymes, artificial organelles, and artificial mammalian cells. Each aspect will be briefly introduced, followed by highlighting efforts that considered key properties of the different mimics. Finally, the current challenges and opportunities will be outlined. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

Original languageEnglish
Article numbere1683
JournalWiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Publication statusPublished - 1 May 2021

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Publisher Copyright:
© 2020 Wiley Periodicals LLC.

Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • artificial biology, artificial cells, artificial enzymes, bottom-up assembly, cell mimicry

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