Cell mimicry as a bottom-up strategy for hierarchical engineering of nature-inspired entities

TY - JOUR

T1 - Cell mimicry as a bottom-up strategy for hierarchical engineering of nature-inspired entities

AU - Qian, Xiaomin

AU - Nymann Westensee, Isabella

AU - Brodszkij, Edit

AU - Städler, Brigitte

N1 - Publisher Copyright: © 2020 Wiley Periodicals LLC. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Artificial biology is an emerging concept that aims to design and engineer the structure and function of natural cells, organelles, or biomolecules with a combination of biological and abiotic building blocks. Cell mimicry focuses on concepts that have the potential to be integrated with mammalian cells and tissue. In this feature article, we will emphasize the advancements in the past 3–4 years (2017-present) that are dedicated to artificial enzymes, artificial organelles, and artificial mammalian cells. Each aspect will be briefly introduced, followed by highlighting efforts that considered key properties of the different mimics. Finally, the current challenges and opportunities will be outlined. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

AB - Artificial biology is an emerging concept that aims to design and engineer the structure and function of natural cells, organelles, or biomolecules with a combination of biological and abiotic building blocks. Cell mimicry focuses on concepts that have the potential to be integrated with mammalian cells and tissue. In this feature article, we will emphasize the advancements in the past 3–4 years (2017-present) that are dedicated to artificial enzymes, artificial organelles, and artificial mammalian cells. Each aspect will be briefly introduced, followed by highlighting efforts that considered key properties of the different mimics. Finally, the current challenges and opportunities will be outlined. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

KW - artificial biology

KW - artificial cells

KW - artificial enzymes

KW - bottom-up assembly

KW - cell mimicry

UR - http://www.scopus.com/inward/record.url?scp=85096791985&partnerID=8YFLogxK

U2 - 10.1002/wnan.1683

DO - 10.1002/wnan.1683

M3 - Journal article

C2 - 33205632

AN - SCOPUS:85096791985

SN - 1939-0041

VL - 13

JO - Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

JF - Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

IS - 3

M1 - e1683

ER -