CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells

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CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells. / Hansen, Aida S; Slater, Josefine; Biltoft, Mette; Bundgaard, Bettina B; Møller, Bjarne K; Höllsberg, Per.

In: Immunology Letters, Vol. 200, 08.2018, p. 26-32.

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@article{59437a6ab0034a009cc7536dab7fd549,
title = "CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells",
abstract = "Similar to CD4+ T cells, precursor CD8+ T cells are thought to depend on a co-stimulatory signal through CD28 for proliferation and differentiation into effector cells. CD46 is another co-stimulatory receptor that promotes differentiation of CD4+ T-helper cells type 1 (Th1 cells) into a regulatory phenotype with a switch from IFN-γ towards IL-10-secretion over time. Whether CD46 exerts a similar function on CD8+ T cells remains to be fully elucidated. Here, we demonstrate that CD46 co-stimulation induced secretion of IFN-γ as well as expansion of IFN-γ-secreting CD8+ T cells. In contrast to CD46 co-stimulation of CD4+ T cells, CD8+ T cells did not differentiate into a regulatory IL-10-secreting phenotype. This demonstrates that CD46 is a co-stimulatory receptor on CD8+ T cells, and that it exerts separate functions during CD4+ and CD8+ T-cell differentiation.",
author = "Hansen, {Aida S} and Josefine Slater and Mette Biltoft and Bundgaard, {Bettina B} and M{\o}ller, {Bjarne K} and Per H{\"o}llsberg",
note = "Copyright {\textcopyright} 2018 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.",
year = "2018",
month = aug,
doi = "10.1016/j.imlet.2018.06.003",
language = "English",
volume = "200",
pages = "26--32",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells

AU - Hansen, Aida S

AU - Slater, Josefine

AU - Biltoft, Mette

AU - Bundgaard, Bettina B

AU - Møller, Bjarne K

AU - Höllsberg, Per

N1 - Copyright © 2018 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

PY - 2018/8

Y1 - 2018/8

N2 - Similar to CD4+ T cells, precursor CD8+ T cells are thought to depend on a co-stimulatory signal through CD28 for proliferation and differentiation into effector cells. CD46 is another co-stimulatory receptor that promotes differentiation of CD4+ T-helper cells type 1 (Th1 cells) into a regulatory phenotype with a switch from IFN-γ towards IL-10-secretion over time. Whether CD46 exerts a similar function on CD8+ T cells remains to be fully elucidated. Here, we demonstrate that CD46 co-stimulation induced secretion of IFN-γ as well as expansion of IFN-γ-secreting CD8+ T cells. In contrast to CD46 co-stimulation of CD4+ T cells, CD8+ T cells did not differentiate into a regulatory IL-10-secreting phenotype. This demonstrates that CD46 is a co-stimulatory receptor on CD8+ T cells, and that it exerts separate functions during CD4+ and CD8+ T-cell differentiation.

AB - Similar to CD4+ T cells, precursor CD8+ T cells are thought to depend on a co-stimulatory signal through CD28 for proliferation and differentiation into effector cells. CD46 is another co-stimulatory receptor that promotes differentiation of CD4+ T-helper cells type 1 (Th1 cells) into a regulatory phenotype with a switch from IFN-γ towards IL-10-secretion over time. Whether CD46 exerts a similar function on CD8+ T cells remains to be fully elucidated. Here, we demonstrate that CD46 co-stimulation induced secretion of IFN-γ as well as expansion of IFN-γ-secreting CD8+ T cells. In contrast to CD46 co-stimulation of CD4+ T cells, CD8+ T cells did not differentiate into a regulatory IL-10-secreting phenotype. This demonstrates that CD46 is a co-stimulatory receptor on CD8+ T cells, and that it exerts separate functions during CD4+ and CD8+ T-cell differentiation.

U2 - 10.1016/j.imlet.2018.06.003

DO - 10.1016/j.imlet.2018.06.003

M3 - Journal article

C2 - 29902483

VL - 200

SP - 26

EP - 32

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

ER -