Catalytic Enantioselective [10+4] Cycloadditions

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The first peri- and stereoselective [10+4] cycloaddition between catalytically generated amino isobenzofulvenes and electron-deficient dienes is described. The highly stereoselective catalytic [10+4] cycloaddition exhibits a broad scope with high yields, reflecting a robust higher-order cycloaddition. Experimental and computational investigations support a kinetic distribution of intermediate rotamers dictating the enantioselectivity, which relies heavily on additive effects.

Original languageEnglish
JournalAngewandte Chemie - International Edition
Pages (from-to)13182-13186
Number of pages5
Publication statusPublished - 1 Oct 2018

    Research areas

  • asymmetric synthesis, cycloaddition, density-functional calculations, organocatalysis

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