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Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis

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Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis. / Hackenberg, Thomas; Juul, Trine; Auzina, Aija et al.

In: Plant Cell, Vol. 25, No. 11, 27.11.2013, p. 4616-4626.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hackenberg, T, Juul, T, Auzina, A, Gwizdz, S, Malolepszy, A, Van Der Kelen, K, Dam, S, Bressendorff, S, Lorentzen, AM, Roepstorff, P, Lehmann Nielsen, K, Jørgensen, J-E, Hofius, D, Van Breusegem, F, Petersen, M & Andersen, SU 2013, 'Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis', Plant Cell, vol. 25, no. 11, pp. 4616-4626. https://doi.org/10.1105/tpc.113.117192

APA

Hackenberg, T., Juul, T., Auzina, A., Gwizdz, S., Malolepszy, A., Van Der Kelen, K., Dam, S., Bressendorff, S., Lorentzen, A. M., Roepstorff, P., Lehmann Nielsen, K., Jørgensen, J-E., Hofius, D., Van Breusegem, F., Petersen, M., & Andersen, S. U. (2013). Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis. Plant Cell, 25(11), 4616-4626. https://doi.org/10.1105/tpc.113.117192

CBE

Hackenberg T, Juul T, Auzina A, Gwizdz S, Malolepszy A, Van Der Kelen K, Dam S, Bressendorff S, Lorentzen AM, Roepstorff P, et al. 2013. Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis. Plant Cell. 25(11):4616-4626. https://doi.org/10.1105/tpc.113.117192

MLA

Vancouver

Hackenberg T, Juul T, Auzina A, Gwizdz S, Malolepszy A, Van Der Kelen K et al. Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis. Plant Cell. 2013 Nov 27;25(11):4616-4626. doi: 10.1105/tpc.113.117192

Author

Hackenberg, Thomas ; Juul, Trine ; Auzina, Aija et al. / Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis. In: Plant Cell. 2013 ; Vol. 25, No. 11. pp. 4616-4626.

Bibtex

@article{cb093e7ace6f497db4587e449460b165,
title = "Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis",
abstract = "Programmed cell death often depends on generation of reactive oxygen species, which can be detoxified by antioxidative enzymes, including catalases. We previously isolated catalase-deficient mutants (cat2) in a screen for resistance to hydroxyurea-induced cell death. Here, we identify an Arabidopsis thaliana hydroxyurea-resistant autophagy mutant, atg2, which also shows reduced sensitivity to cell death triggered by the bacterial effector avrRpm1. To test if catalase deficiency likewise affected both hydroxyurea and avrRpm1 sensitivity, we selected mutants with extremely low catalase activities and showed that they carried mutations in a gene that we named NO CATALASE ACTIVITY1 (NCA1). nca1 mutants showed severely reduced activities of all three catalase isoforms in Arabidopsis, and loss of NCA1 function led to strong suppression of RPM1-triggered cell death. Basal and starvation-induced autophagy appeared normal in the nca1 and cat2 mutants. By contrast, autophagic degradation induced by avrRpm1 challenge was compromised, indicating that catalase acted upstream of immunity-triggered autophagy. The direct interaction of catalase with reactive oxygen species could allow catalase to act as a molecular link between reactive oxygen species and the promotion of autophagy-dependent cell death.",
author = "Thomas Hackenberg and Trine Juul and Aija Auzina and Sonia Gwizdz and Anna Malolepszy and {Van Der Kelen}, Katrien and Svend Dam and Simon Bressendorff and Lorentzen, {Andrea Maria} and Peter Roepstorff and {Lehmann Nielsen}, K{\aa}re and Jan-Elo J{\o}rgensen and Daniel Hofius and {Van Breusegem}, Frank and Morten Petersen and Andersen, {Stig Uggerh{\o}j}",
year = "2013",
month = nov,
day = "27",
doi = "10.1105/tpc.113.117192",
language = "English",
volume = "25",
pages = "4616--4626",
journal = "Plant Cell",
issn = "1040-4651",
publisher = "American Society of Plant Biologists",
number = "11",

}

RIS

TY - JOUR

T1 - Catalase and NO CATALASE ACTIVITY1 Promote Autophagy-Dependent Cell Death in Arabidopsis

AU - Hackenberg, Thomas

AU - Juul, Trine

AU - Auzina, Aija

AU - Gwizdz, Sonia

AU - Malolepszy, Anna

AU - Van Der Kelen, Katrien

AU - Dam, Svend

AU - Bressendorff, Simon

AU - Lorentzen, Andrea Maria

AU - Roepstorff, Peter

AU - Lehmann Nielsen, Kåre

AU - Jørgensen, Jan-Elo

AU - Hofius, Daniel

AU - Van Breusegem, Frank

AU - Petersen, Morten

AU - Andersen, Stig Uggerhøj

PY - 2013/11/27

Y1 - 2013/11/27

N2 - Programmed cell death often depends on generation of reactive oxygen species, which can be detoxified by antioxidative enzymes, including catalases. We previously isolated catalase-deficient mutants (cat2) in a screen for resistance to hydroxyurea-induced cell death. Here, we identify an Arabidopsis thaliana hydroxyurea-resistant autophagy mutant, atg2, which also shows reduced sensitivity to cell death triggered by the bacterial effector avrRpm1. To test if catalase deficiency likewise affected both hydroxyurea and avrRpm1 sensitivity, we selected mutants with extremely low catalase activities and showed that they carried mutations in a gene that we named NO CATALASE ACTIVITY1 (NCA1). nca1 mutants showed severely reduced activities of all three catalase isoforms in Arabidopsis, and loss of NCA1 function led to strong suppression of RPM1-triggered cell death. Basal and starvation-induced autophagy appeared normal in the nca1 and cat2 mutants. By contrast, autophagic degradation induced by avrRpm1 challenge was compromised, indicating that catalase acted upstream of immunity-triggered autophagy. The direct interaction of catalase with reactive oxygen species could allow catalase to act as a molecular link between reactive oxygen species and the promotion of autophagy-dependent cell death.

AB - Programmed cell death often depends on generation of reactive oxygen species, which can be detoxified by antioxidative enzymes, including catalases. We previously isolated catalase-deficient mutants (cat2) in a screen for resistance to hydroxyurea-induced cell death. Here, we identify an Arabidopsis thaliana hydroxyurea-resistant autophagy mutant, atg2, which also shows reduced sensitivity to cell death triggered by the bacterial effector avrRpm1. To test if catalase deficiency likewise affected both hydroxyurea and avrRpm1 sensitivity, we selected mutants with extremely low catalase activities and showed that they carried mutations in a gene that we named NO CATALASE ACTIVITY1 (NCA1). nca1 mutants showed severely reduced activities of all three catalase isoforms in Arabidopsis, and loss of NCA1 function led to strong suppression of RPM1-triggered cell death. Basal and starvation-induced autophagy appeared normal in the nca1 and cat2 mutants. By contrast, autophagic degradation induced by avrRpm1 challenge was compromised, indicating that catalase acted upstream of immunity-triggered autophagy. The direct interaction of catalase with reactive oxygen species could allow catalase to act as a molecular link between reactive oxygen species and the promotion of autophagy-dependent cell death.

U2 - 10.1105/tpc.113.117192

DO - 10.1105/tpc.113.117192

M3 - Journal article

C2 - 24285797

VL - 25

SP - 4616

EP - 4626

JO - Plant Cell

JF - Plant Cell

SN - 1040-4651

IS - 11

ER -