Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis

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  • Anne F Christensen
  • ,
  • Hanne Lindegaard
  • ,
  • Kim Hørslev-Petersen, Center Sønderjylland, Denmark
  • Merete Lund Hetland, Institut for Ortopædi og Intern Medicin, Denmark
  • Bo Ejbjerg
  • ,
  • Kristian Stengaard-Pedersen
  • Søren Jacobsen, Institut for Ortopædi og Intern Medicin, Denmark
  • Tine Lottenburger, Reumatologi, Denmark
  • Torkell Ellingsen, Denmark
  • Lis S Andersen
  • ,
  • Ib Hansen
  • Henrik Skjødt, Institut for Ortopædi og Intern Medicin, Denmark
  • Jens K Pedersen
  • ,
  • Ulrik B Lauridsen
  • ,
  • Anders Jørgen Svendsen, Epidemiologi, Denmark
  • Ulrik Tarp, Denmark
  • Jan Pødenphant, Institut for Ortopædi og Intern Medicin, Denmark
  • Mikkel Østergaard, Institut for Ortopædi og Intern Medicin, Denmark
  • Peter Junker, Reumatologi, Denmark
Cyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative rheumatoid arthritis (RA) have been suggested as 2 distinctive disease subsets with respect to disease activity and prognosis. Previously, we proposed that anti-CCP antibodies might have a chondrocyte-suppressive effect. We aimed to compare circulating cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in untreated anti-CCP-positive and anti-CCP-negative RA, and to study the temporal pattern of COMP through 4 years of treatment, including the relationship to imaging and clinical findings.
Original languageEnglish
JournalJournal of Rheumatology
Volume38
Issue8
Pages (from-to)1563-8
Number of pages6
ISSN0315-162X
DOIs
Publication statusPublished - 2011

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