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Cardiac dysfunction among soft tissue sarcoma patients in Denmark

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Cardiac dysfunction among soft tissue sarcoma patients in Denmark. / Shantakumar, Sumitra; Olsen, Morten; Vo, Thao T; Nørgaard, Mette; Pedersen, Lars.

In: Clinical epidemiology, Vol. 8, 2016, p. 53-9.

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Shantakumar, Sumitra ; Olsen, Morten ; Vo, Thao T ; Nørgaard, Mette ; Pedersen, Lars. / Cardiac dysfunction among soft tissue sarcoma patients in Denmark. In: Clinical epidemiology. 2016 ; Vol. 8. pp. 53-9.

Bibtex

@article{23a2a4b98a9a4ccb8f53c9593363740d,
title = "Cardiac dysfunction among soft tissue sarcoma patients in Denmark",
abstract = "PURPOSE: Soft tissue sarcoma (STS) patients may experience post-treatment cardiotoxicity, yet no population-based data exist. We examined the incidence of left ventricular ejection fraction (LVEF) decline, heart failure, and cardiac death following STS diagnosis among adults, using Danish patient registries and medical record review.PATIENTS AND METHODS: LVEF decline was examined in a regional cohort of STS patients diagnosed during 1997-2011 in Western Denmark for whom cardiac imaging data were available. LVEF decline was defined as an absolute decline from baseline to follow-up of 10{\%} or more, or, where baseline imaging was not available, a decline below the lower limit of normal (or 40{\%}) for a follow-up LVEF. Heart failure and cardiac death were investigated in a national Danish cohort of all STS patients diagnosed from 2000 to 2009. We followed patients from STS diagnosis until heart failure, cardiac death, emigration or December 31, 2012 (whichever occurred first).RESULTS: The incidence rate of LVEF decline for the regional cohort with follow-up data (N=100, five events) or baseline and follow-up measurements (N=75, 19 events) was 16.8 (95{\%} confidence interval [CI]: 7.0-40.3) and 108 (95{\%} CI: 69-170), respectively, per 1,000 person-years. In the national cohort (N=1,187), the incidence of heart failure (40 events) and cardiac death (15 events) was 7.3 (95{\%} CI: 5.4-10.0) and 2.7 (95{\%} CI: 1.6-4.5), respectively, per 1,000 person-years. The strongest predictors of heart failure were doxorubicin treatment (hazard ratio [HR] =2.2, 95{\%} CI: 0.5-10.2) and pre-existing cardiovascular disease (HR=6.3, 95{\%} CI: 0.98-40.6).CONCLUSION: LVEF decline occurred more frequently compared to heart failure or cardiac death in a nationally representative cohort of Danish STS patients.",
keywords = "Journal Article",
author = "Sumitra Shantakumar and Morten Olsen and Vo, {Thao T} and Mette N{\o}rgaard and Lars Pedersen",
year = "2016",
doi = "10.2147/CLEP.S100779",
language = "English",
volume = "8",
pages = "53--9",
journal = "Clinical Epidemiology",
issn = "1179-1349",
publisher = "Dove Medical Press Ltd.(Dovepress)",

}

RIS

TY - JOUR

T1 - Cardiac dysfunction among soft tissue sarcoma patients in Denmark

AU - Shantakumar, Sumitra

AU - Olsen, Morten

AU - Vo, Thao T

AU - Nørgaard, Mette

AU - Pedersen, Lars

PY - 2016

Y1 - 2016

N2 - PURPOSE: Soft tissue sarcoma (STS) patients may experience post-treatment cardiotoxicity, yet no population-based data exist. We examined the incidence of left ventricular ejection fraction (LVEF) decline, heart failure, and cardiac death following STS diagnosis among adults, using Danish patient registries and medical record review.PATIENTS AND METHODS: LVEF decline was examined in a regional cohort of STS patients diagnosed during 1997-2011 in Western Denmark for whom cardiac imaging data were available. LVEF decline was defined as an absolute decline from baseline to follow-up of 10% or more, or, where baseline imaging was not available, a decline below the lower limit of normal (or 40%) for a follow-up LVEF. Heart failure and cardiac death were investigated in a national Danish cohort of all STS patients diagnosed from 2000 to 2009. We followed patients from STS diagnosis until heart failure, cardiac death, emigration or December 31, 2012 (whichever occurred first).RESULTS: The incidence rate of LVEF decline for the regional cohort with follow-up data (N=100, five events) or baseline and follow-up measurements (N=75, 19 events) was 16.8 (95% confidence interval [CI]: 7.0-40.3) and 108 (95% CI: 69-170), respectively, per 1,000 person-years. In the national cohort (N=1,187), the incidence of heart failure (40 events) and cardiac death (15 events) was 7.3 (95% CI: 5.4-10.0) and 2.7 (95% CI: 1.6-4.5), respectively, per 1,000 person-years. The strongest predictors of heart failure were doxorubicin treatment (hazard ratio [HR] =2.2, 95% CI: 0.5-10.2) and pre-existing cardiovascular disease (HR=6.3, 95% CI: 0.98-40.6).CONCLUSION: LVEF decline occurred more frequently compared to heart failure or cardiac death in a nationally representative cohort of Danish STS patients.

AB - PURPOSE: Soft tissue sarcoma (STS) patients may experience post-treatment cardiotoxicity, yet no population-based data exist. We examined the incidence of left ventricular ejection fraction (LVEF) decline, heart failure, and cardiac death following STS diagnosis among adults, using Danish patient registries and medical record review.PATIENTS AND METHODS: LVEF decline was examined in a regional cohort of STS patients diagnosed during 1997-2011 in Western Denmark for whom cardiac imaging data were available. LVEF decline was defined as an absolute decline from baseline to follow-up of 10% or more, or, where baseline imaging was not available, a decline below the lower limit of normal (or 40%) for a follow-up LVEF. Heart failure and cardiac death were investigated in a national Danish cohort of all STS patients diagnosed from 2000 to 2009. We followed patients from STS diagnosis until heart failure, cardiac death, emigration or December 31, 2012 (whichever occurred first).RESULTS: The incidence rate of LVEF decline for the regional cohort with follow-up data (N=100, five events) or baseline and follow-up measurements (N=75, 19 events) was 16.8 (95% confidence interval [CI]: 7.0-40.3) and 108 (95% CI: 69-170), respectively, per 1,000 person-years. In the national cohort (N=1,187), the incidence of heart failure (40 events) and cardiac death (15 events) was 7.3 (95% CI: 5.4-10.0) and 2.7 (95% CI: 1.6-4.5), respectively, per 1,000 person-years. The strongest predictors of heart failure were doxorubicin treatment (hazard ratio [HR] =2.2, 95% CI: 0.5-10.2) and pre-existing cardiovascular disease (HR=6.3, 95% CI: 0.98-40.6).CONCLUSION: LVEF decline occurred more frequently compared to heart failure or cardiac death in a nationally representative cohort of Danish STS patients.

KW - Journal Article

U2 - 10.2147/CLEP.S100779

DO - 10.2147/CLEP.S100779

M3 - Journal article

VL - 8

SP - 53

EP - 59

JO - Clinical Epidemiology

JF - Clinical Epidemiology

SN - 1179-1349

ER -