Cardiac computed tomography-derived coronary artery volume to myocardial mass

Abdul Rahman Ihdayhid; Timothy A Fairbairn; Gaurav S Gulsin; Georgios Tzimas; Edward Danehy; Adam Updegrove; Jesper M Jensen; Charles A Taylor; Jeroen J Bax; Stephanie L Sellers; Jonathon A Leipsic; Bjarne L Nørgaard

doi:10.1016/j.jcct.2021.10.007

Cardiac computed tomography-derived coronary artery volume to myocardial mass

Abdul Rahman Ihdayhid, Timothy A Fairbairn, Gaurav S Gulsin, Georgios Tzimas, Edward Danehy, Adam Updegrove, Jesper M Jensen, Charles A Taylor, Jeroen J Bax, Stephanie L Sellers, Jonathon A Leipsic, Bjarne L Nørgaard

Department of Clinical Medicine - The Department of Cardiological Medicine B

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Abstract

In the absence of disease impacting the coronary arteries or myocardium, there exists a linear relationship between vessel volume and myocardial mass to ensure balanced distribution of blood supply. This balance may be disturbed in diseases of either the coronary artery tree, the myocardium, or both. However, in contemporary evaluation the coronary artery anatomy and myocardium are assessed separately. Recently the coronary lumen volume to myocardial mass ratio (V/M), measured noninvasively using coronary computed tomography angiography (CTCA), has emerged as an integrated measure of myocardial blood supply and demand in vivo. This has the potential to yield new insights into diseases where this balance is altered, thus impacting clinical diagnoses and management. In this review, we outline the scientific methodology underpinning CTCA-derived measurement of V/M. We describe recent studies describing alterations in V/M across a range of cardiovascular conditions, including coronary artery disease, cardiomyopathies and coronary microvascular dysfunction. Lastly, we highlight areas of unmet research need and future directions, where V/M may further enhance our understanding of the pathophysiology of cardiovascular disease.

Original language	English
Journal	Journal of Cardiovascular Computed Tomography
Volume	16
Issue	3
Pages (from-to)	198-206
Number of pages	9
ISSN	1934-5925
DOIs	https://doi.org/10.1016/j.jcct.2021.10.007
Publication status	Published - May 2022

Keywords

Coronary computed tomography angiography
Coronary volume/mass
Fractional flow reserve derived from computed tomography

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Cardiac computed tomography-derived coronary artery volume to myocardial massFinal published version, 1.55 MBLicence: CC BY

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Ihdayhid, A. R., Fairbairn, T. A., Gulsin, G. S., Tzimas, G., Danehy, E., Updegrove, A., Jensen, J. M., Taylor, C. A., Bax, J. J., Sellers, S. L., Leipsic, J. A., & Nørgaard, B. L. (2022). Cardiac computed tomography-derived coronary artery volume to myocardial mass. Journal of Cardiovascular Computed Tomography, 16(3), 198-206. https://doi.org/10.1016/j.jcct.2021.10.007

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title = "Cardiac computed tomography-derived coronary artery volume to myocardial mass",

abstract = "In the absence of disease impacting the coronary arteries or myocardium, there exists a linear relationship between vessel volume and myocardial mass to ensure balanced distribution of blood supply. This balance may be disturbed in diseases of either the coronary artery tree, the myocardium, or both. However, in contemporary evaluation the coronary artery anatomy and myocardium are assessed separately. Recently the coronary lumen volume to myocardial mass ratio (V/M), measured noninvasively using coronary computed tomography angiography (CTCA), has emerged as an integrated measure of myocardial blood supply and demand in vivo. This has the potential to yield new insights into diseases where this balance is altered, thus impacting clinical diagnoses and management. In this review, we outline the scientific methodology underpinning CTCA-derived measurement of V/M. We describe recent studies describing alterations in V/M across a range of cardiovascular conditions, including coronary artery disease, cardiomyopathies and coronary microvascular dysfunction. Lastly, we highlight areas of unmet research need and future directions, where V/M may further enhance our understanding of the pathophysiology of cardiovascular disease.",

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doi = "10.1016/j.jcct.2021.10.007",

language = "English",

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Cardiac computed tomography-derived coronary artery volume to myocardial mass. / Ihdayhid, Abdul Rahman; Fairbairn, Timothy A; Gulsin, Gaurav S et al.
In: Journal of Cardiovascular Computed Tomography, Vol. 16, No. 3, 05.2022, p. 198-206.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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AU - Ihdayhid, Abdul Rahman

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AU - Gulsin, Gaurav S

AU - Tzimas, Georgios

AU - Danehy, Edward

AU - Updegrove, Adam

AU - Jensen, Jesper M

AU - Taylor, Charles A

AU - Bax, Jeroen J

AU - Sellers, Stephanie L

AU - Leipsic, Jonathon A

AU - Nørgaard, Bjarne L

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N2 - In the absence of disease impacting the coronary arteries or myocardium, there exists a linear relationship between vessel volume and myocardial mass to ensure balanced distribution of blood supply. This balance may be disturbed in diseases of either the coronary artery tree, the myocardium, or both. However, in contemporary evaluation the coronary artery anatomy and myocardium are assessed separately. Recently the coronary lumen volume to myocardial mass ratio (V/M), measured noninvasively using coronary computed tomography angiography (CTCA), has emerged as an integrated measure of myocardial blood supply and demand in vivo. This has the potential to yield new insights into diseases where this balance is altered, thus impacting clinical diagnoses and management. In this review, we outline the scientific methodology underpinning CTCA-derived measurement of V/M. We describe recent studies describing alterations in V/M across a range of cardiovascular conditions, including coronary artery disease, cardiomyopathies and coronary microvascular dysfunction. Lastly, we highlight areas of unmet research need and future directions, where V/M may further enhance our understanding of the pathophysiology of cardiovascular disease.

AB - In the absence of disease impacting the coronary arteries or myocardium, there exists a linear relationship between vessel volume and myocardial mass to ensure balanced distribution of blood supply. This balance may be disturbed in diseases of either the coronary artery tree, the myocardium, or both. However, in contemporary evaluation the coronary artery anatomy and myocardium are assessed separately. Recently the coronary lumen volume to myocardial mass ratio (V/M), measured noninvasively using coronary computed tomography angiography (CTCA), has emerged as an integrated measure of myocardial blood supply and demand in vivo. This has the potential to yield new insights into diseases where this balance is altered, thus impacting clinical diagnoses and management. In this review, we outline the scientific methodology underpinning CTCA-derived measurement of V/M. We describe recent studies describing alterations in V/M across a range of cardiovascular conditions, including coronary artery disease, cardiomyopathies and coronary microvascular dysfunction. Lastly, we highlight areas of unmet research need and future directions, where V/M may further enhance our understanding of the pathophysiology of cardiovascular disease.

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Cardiac computed tomography-derived coronary artery volume to myocardial mass

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