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Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

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Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. / Gonzalez, Santiago F.; Lukacs-Kornek, Veronika; Kuligowski, Michael P. et al.

In: Nature Immunology, Vol. 11, No. 5, 05.2010, p. 427-435.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Gonzalez, SF, Lukacs-Kornek, V, Kuligowski, MP, Pitcher, LA, Degn, SE, Kim, Y-A, Cloninger, MJ, Martinez-Pomares, L, Gordon, S, Turley, SJ & Carroll, MC 2010, 'Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes', Nature Immunology, vol. 11, no. 5, pp. 427-435.

APA

Gonzalez, S. F., Lukacs-Kornek, V., Kuligowski, M. P., Pitcher, L. A., Degn, S. E., Kim, Y-A., Cloninger, M. J., Martinez-Pomares, L., Gordon, S., Turley, S. J., & Carroll, M. C. (2010). Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. Nature Immunology, 11(5), 427-435.

CBE

Gonzalez SF, Lukacs-Kornek V, Kuligowski MP, Pitcher LA, Degn SE, Kim Y-A, Cloninger MJ, Martinez-Pomares L, Gordon S, Turley SJ, et al. 2010. Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. Nature Immunology. 11(5):427-435.

MLA

Gonzalez, Santiago F. et al. "Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes". Nature Immunology. 2010, 11(5). 427-435.

Vancouver

Gonzalez SF, Lukacs-Kornek V, Kuligowski MP, Pitcher LA, Degn SE, Kim Y-A et al. Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. Nature Immunology. 2010 May;11(5):427-435.

Author

Gonzalez, Santiago F. ; Lukacs-Kornek, Veronika ; Kuligowski, Michael P. et al. / Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. In: Nature Immunology. 2010 ; Vol. 11, No. 5. pp. 427-435.

Bibtex

@article{788243a457534bd0b9249ff18e4a7198,
title = "Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes",
abstract = "A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including multiphoton intravital imaging, we found that antigen capture by sinus-lining macrophages was important for limiting the systemic spread of virus but not for the generation of influenza-specific humoral immunity. Instead, we found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. Thus, our results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination.",
author = "Gonzalez, {Santiago F.} and Veronika Lukacs-Kornek and Kuligowski, {Michael P.} and Pitcher, {Lisa A.} and Degn, {S{\o}ren Egedal} and Young-A Kim and Cloninger, {Mary J.} and Luisa Martinez-Pomares and Siamon Gordon and Turley, {Shannon J.} and Carroll, {Michael C.}",
year = "2010",
month = may,
language = "English",
volume = "11",
pages = "427--435",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

AU - Gonzalez, Santiago F.

AU - Lukacs-Kornek, Veronika

AU - Kuligowski, Michael P.

AU - Pitcher, Lisa A.

AU - Degn, Søren Egedal

AU - Kim, Young-A

AU - Cloninger, Mary J.

AU - Martinez-Pomares, Luisa

AU - Gordon, Siamon

AU - Turley, Shannon J.

AU - Carroll, Michael C.

PY - 2010/5

Y1 - 2010/5

N2 - A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including multiphoton intravital imaging, we found that antigen capture by sinus-lining macrophages was important for limiting the systemic spread of virus but not for the generation of influenza-specific humoral immunity. Instead, we found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. Thus, our results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination.

AB - A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including multiphoton intravital imaging, we found that antigen capture by sinus-lining macrophages was important for limiting the systemic spread of virus but not for the generation of influenza-specific humoral immunity. Instead, we found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. Thus, our results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination.

M3 - Journal article

VL - 11

SP - 427

EP - 435

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 5

ER -