Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease

Lasse Stensvig Madsen*, Peter Parbo, Rola Ismail, Hanne Gottrup, Leif Østergaard, David J Brooks, Simon Fristed Eskildsen

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Alterations in cerebral perfusion is increasingly considered to play a crucial role in Alzheimer’s disease (AD) and together with accumulated amyloid-β, deficiencies in the brain microvascular circulation may result in local hypoxia. Here, we studied alterations in cerebral circulation and the correlation between amyloid-β load and cerebral perfusion in prodromal AD (pAD). Using dynamic susceptibility contrast MRI and PET, we evaluated cerebral perfusion and amyloid-β levels in 19 individuals with mild cognitive impairment (MCI) and high amyloid-β load (pAD-MCI), 13 MCI individuals without AD pathology and 21 healthy controls. The pAD-MCI group showed significantly lower microvascular blood flow and significantly higher heterogeneity of microvascular blood transit times (p < 0.01) compared with the other 2 groups. Additionally, in the pAD-MCI group raised amyloid-β levels correlated with decreased microvascular blood flow and increased heterogeneity of microvascular blood flow in frontal and temporal areas (p < 0.01). These results indicate a close connection between levels of amyloid-β deposition and brain microvascular perfusion in pAD. A vicious cycle may be established where amyloid-β load and deficiencies in brain perfusion may reinforce each other.
Original languageEnglish
JournalNeurobiology of Aging
Volume123
Pages (from-to)1-9
Number of pages9
ISSN0197-4580
DOIs
Publication statusPublished - Mar 2023

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