Cannabinoid-Induced Immunomodulation during Viral Infections: A Focus on Mitochondria

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

DOI

  • Cherifa Beji, Geol Survey Canada, Natural Resources Canada, Lands & Minerals Sector - Natural Resources Canada, Geological Survey of Canada, Nat Resources Canada
  • ,
  • Hamza Loucif, Geol Survey Canada, Natural Resources Canada, Lands & Minerals Sector - Natural Resources Canada, Geological Survey of Canada, Nat Resources Canada
  • ,
  • Roman Telittchenko, Geol Survey Canada, Natural Resources Canada, Lands & Minerals Sector - Natural Resources Canada, Geological Survey of Canada, Nat Resources Canada
  • ,
  • David Olagnier
  • Xavier Dagenais-Lussier, Geol Survey Canada, Natural Resources Canada, Lands & Minerals Sector - Natural Resources Canada, Geological Survey of Canada, Nat Resources Canada
  • ,
  • Julien van Grevenynghe, Geol Survey Canada, Natural Resources Canada, Lands & Minerals Sector - Natural Resources Canada, Geological Survey of Canada, Nat Resources Canada

This review examines the impact of cannabinoids on viral infections, as well as its effects on the mitochondria of the nervous and immune system. The paper conveys information about the beneficial and negative impacts of cannabinoids on viral infections, especially HIV-1. These include effects on the inflammatory response as well as neuroprotective effects. We also explore non-apoptotic mitochondrial pathways modulated by the activity of cannabinoids, resulting in modifications to cellular functions. As a large part of the literature derives from studies of the nervous system, we first compile the information related to mitochondrial functions in this system, particularly through the CB1 receptor. Finally, we reflect on how this knowledge could complement what has been demonstrated in the immune system, especially in the context of the CB2 receptor and Ca2+ uptake. The overall conclusion of the review is that cannabinoids have the potential to affect a broad range of cell types through mitochondrial modulation, be it through receptor-specific action or not, and that this pathway has a potential implication in cases of viral infection.

Original languageEnglish
Article number875
JournalViruses
Volume12
Issue8
Number of pages16
ISSN1999-4915
DOIs
Publication statusPublished - 2020

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