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Cancer Genome Evolutionary Trajectories in Metastasis

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Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for genomic drivers of metastasis and explore studies investigating modes of metastatic spread.

Original languageEnglish
JournalCancer Cell
Pages (from-to)8-19
Publication statusPublished - Jan 2020

    Research areas

  • cancer drivers, cancer evolution, cancer genomics, clonal heterogeneity, evolutionary trajectories, immune escape, metastasis, metastatic drivers, monoclonal dissemination, polyclonal dissemination

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ID: 183066710