Can we define and characterize the aging lower urinary tract? ICI-RS 2015

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Can we define and characterize the aging lower urinary tract? ICI-RS 2015. / Vahabi, Bahareh; Wagg, Adrian S.; Rosier, Peter F. W. M.; Rademakers, Kevin L. J.; Denys, Marie-Astrid; Pontari, Michel; Lovick, Thelma; Valentini, Francoise A.; Nelson, Pierre P.; Andersson, Karl-Erik; Fry, Christopher H.

In: Neurourology and Urodynamics, Vol. 36, No. 4, 2017, p. 854-858.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Vahabi, B, Wagg, AS, Rosier, PFWM, Rademakers, KLJ, Denys, M-A, Pontari, M, Lovick, T, Valentini, FA, Nelson, PP, Andersson, K-E & Fry, CH 2017, 'Can we define and characterize the aging lower urinary tract? ICI-RS 2015', Neurourology and Urodynamics, vol. 36, no. 4, pp. 854-858. https://doi.org/10.1002/nau.23035

APA

Vahabi, B., Wagg, A. S., Rosier, P. F. W. M., Rademakers, K. L. J., Denys, M-A., Pontari, M., ... Fry, C. H. (2017). Can we define and characterize the aging lower urinary tract? ICI-RS 2015. Neurourology and Urodynamics, 36(4), 854-858. https://doi.org/10.1002/nau.23035

CBE

Vahabi B, Wagg AS, Rosier PFWM, Rademakers KLJ, Denys M-A, Pontari M, Lovick T, Valentini FA, Nelson PP, Andersson K-E, Fry CH. 2017. Can we define and characterize the aging lower urinary tract? ICI-RS 2015. Neurourology and Urodynamics. 36(4):854-858. https://doi.org/10.1002/nau.23035

MLA

Vahabi, Bahareh et al. "Can we define and characterize the aging lower urinary tract? ICI-RS 2015". Neurourology and Urodynamics. 2017, 36(4). 854-858. https://doi.org/10.1002/nau.23035

Vancouver

Vahabi B, Wagg AS, Rosier PFWM, Rademakers KLJ, Denys M-A, Pontari M et al. Can we define and characterize the aging lower urinary tract? ICI-RS 2015. Neurourology and Urodynamics. 2017;36(4):854-858. https://doi.org/10.1002/nau.23035

Author

Vahabi, Bahareh ; Wagg, Adrian S. ; Rosier, Peter F. W. M. ; Rademakers, Kevin L. J. ; Denys, Marie-Astrid ; Pontari, Michel ; Lovick, Thelma ; Valentini, Francoise A. ; Nelson, Pierre P. ; Andersson, Karl-Erik ; Fry, Christopher H. / Can we define and characterize the aging lower urinary tract? ICI-RS 2015. In: Neurourology and Urodynamics. 2017 ; Vol. 36, No. 4. pp. 854-858.

Bibtex

@article{1ef79cc84165480d955f9b3a1211204d,
title = "Can we define and characterize the aging lower urinary tract? ICI-RS 2015",
abstract = "The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the variable of interest or a time-dependent accumulation of factors that impact on LUT function at rates that differ between individuals. In particular, the accumulation of conditions or agents due to inflammatory states or tissue ischemia is important. Much of the above has been concerned with changes to bladder function and morphology. However, the outflow tract function is also affected, in particular changes to the function of external sphincter skeletal muscle and associated sacral motor nerve control. Nocturia is a cardinal symptom of LUT dysfunction and is more prevalent with aging. Urine production is determined by diurnal changes to the production of certain hormones as well as arterial blood pressure and such diurnal rhythms are blunted in subjects with nocturia, but the causal links remain to be elucidated. Changes to the central nervous control of LUT function with age are also increasingly recognized, whether in mid-brain/brainstem regions that directly affect LUT function or in higher centers that determine psycho-social and emotional factors impinging on the LUT. In particular, the linkage between increasing white matter hyperintensities and LUT dysfunction during aging is recognized but not understood. Overall, a more rational approach is being developed to link LUT dysfunction with factors that accumulate with age, however, the precise causal pathways remain to be characterized. Neurourol. Urodynam. 36:854-858, 2017. (c) 2017 Wiley Periodicals, Inc.",
keywords = "aging, bladder, central nervous system, ischemia, lower urinary tract symptoms, outflow tract, CHRONIC BLADDER ISCHEMIA, NOCTURNAL POLYURIA, DETRUSOR OVERACTIVITY, STRESS-INCONTINENCE, BLOOD-PRESSURE, NEURAL-CONTROL, WOMEN, MICTURITION, SYMPTOMS, MODEL",
author = "Bahareh Vahabi and Wagg, {Adrian S.} and Rosier, {Peter F. W. M.} and Rademakers, {Kevin L. J.} and Marie-Astrid Denys and Michel Pontari and Thelma Lovick and Valentini, {Francoise A.} and Nelson, {Pierre P.} and Karl-Erik Andersson and Fry, {Christopher H.}",
year = "2017",
doi = "10.1002/nau.23035",
language = "English",
volume = "36",
pages = "854--858",
journal = "Neurourology and Urodynamics",
issn = "0733-2467",
publisher = "JohnWiley & Sons, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Can we define and characterize the aging lower urinary tract? ICI-RS 2015

AU - Vahabi, Bahareh

AU - Wagg, Adrian S.

AU - Rosier, Peter F. W. M.

AU - Rademakers, Kevin L. J.

AU - Denys, Marie-Astrid

AU - Pontari, Michel

AU - Lovick, Thelma

AU - Valentini, Francoise A.

AU - Nelson, Pierre P.

AU - Andersson, Karl-Erik

AU - Fry, Christopher H.

PY - 2017

Y1 - 2017

N2 - The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the variable of interest or a time-dependent accumulation of factors that impact on LUT function at rates that differ between individuals. In particular, the accumulation of conditions or agents due to inflammatory states or tissue ischemia is important. Much of the above has been concerned with changes to bladder function and morphology. However, the outflow tract function is also affected, in particular changes to the function of external sphincter skeletal muscle and associated sacral motor nerve control. Nocturia is a cardinal symptom of LUT dysfunction and is more prevalent with aging. Urine production is determined by diurnal changes to the production of certain hormones as well as arterial blood pressure and such diurnal rhythms are blunted in subjects with nocturia, but the causal links remain to be elucidated. Changes to the central nervous control of LUT function with age are also increasingly recognized, whether in mid-brain/brainstem regions that directly affect LUT function or in higher centers that determine psycho-social and emotional factors impinging on the LUT. In particular, the linkage between increasing white matter hyperintensities and LUT dysfunction during aging is recognized but not understood. Overall, a more rational approach is being developed to link LUT dysfunction with factors that accumulate with age, however, the precise causal pathways remain to be characterized. Neurourol. Urodynam. 36:854-858, 2017. (c) 2017 Wiley Periodicals, Inc.

AB - The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the variable of interest or a time-dependent accumulation of factors that impact on LUT function at rates that differ between individuals. In particular, the accumulation of conditions or agents due to inflammatory states or tissue ischemia is important. Much of the above has been concerned with changes to bladder function and morphology. However, the outflow tract function is also affected, in particular changes to the function of external sphincter skeletal muscle and associated sacral motor nerve control. Nocturia is a cardinal symptom of LUT dysfunction and is more prevalent with aging. Urine production is determined by diurnal changes to the production of certain hormones as well as arterial blood pressure and such diurnal rhythms are blunted in subjects with nocturia, but the causal links remain to be elucidated. Changes to the central nervous control of LUT function with age are also increasingly recognized, whether in mid-brain/brainstem regions that directly affect LUT function or in higher centers that determine psycho-social and emotional factors impinging on the LUT. In particular, the linkage between increasing white matter hyperintensities and LUT dysfunction during aging is recognized but not understood. Overall, a more rational approach is being developed to link LUT dysfunction with factors that accumulate with age, however, the precise causal pathways remain to be characterized. Neurourol. Urodynam. 36:854-858, 2017. (c) 2017 Wiley Periodicals, Inc.

KW - aging

KW - bladder

KW - central nervous system

KW - ischemia

KW - lower urinary tract symptoms

KW - outflow tract

KW - CHRONIC BLADDER ISCHEMIA

KW - NOCTURNAL POLYURIA

KW - DETRUSOR OVERACTIVITY

KW - STRESS-INCONTINENCE

KW - BLOOD-PRESSURE

KW - NEURAL-CONTROL

KW - WOMEN

KW - MICTURITION

KW - SYMPTOMS

KW - MODEL

U2 - 10.1002/nau.23035

DO - 10.1002/nau.23035

M3 - Journal article

VL - 36

SP - 854

EP - 858

JO - Neurourology and Urodynamics

JF - Neurourology and Urodynamics

SN - 0733-2467

IS - 4

ER -