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Can a Charged Surfactant Unfold an Uncharged Protein?

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Does sodium dodecyl sulfate (SDS) denature proteins through electrostatic SDS-protein interactions? We show that a protein completely lacking charged side chains is unfolded by SDS in a manner similar to charged proteins, revealing that formal protein charges are not required for SDS-induced protein unfolding or binding.

Original languageEnglish
JournalBiophysical Journal
Pages (from-to)2081-2086
Number of pages6
Publication statusPublished - 4 Dec 2018

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