Campylobacter, Salmonella, and Yersinia antibodies and pregnancy outcome in Danish women with occupational exposure to animals

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  • Bjørn Kantsø, Microbiological Diagnostics and Virology, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen, Denmark, Denmark
  • Anne-Marie Nybo Andersen, Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Denmark
  • Kåre Mølbak, Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark, Denmark
  • Karen Angeliki Krogfelt, Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark, Denmark
  • Tine Brink Henriksen
  • Stine Yde Nielsen

BACKGROUND: The aim of this study was to determine antibody titres against Campylobacter, Salmonella, and Yersinia in a population-based cohort of pregnant women in Denmark in order to evaluate adverse pregnancy outcomes (miscarriage, preterm birth, and small for gestational age) in relation to occupational exposure to animals in women exposed to food producing animals.

METHODS: We used data and blood samples from the Danish National Birth Cohort. Serum samples collected during the first trimester from 192 pregnant women who were occupationally exposed to domestic animals and 188 randomly selected unexposed pregnant women were analysed for IgG, IgM, and IgA antibodies against Campylobacter, Salmonella, and Yersinia. Pregnancy outcomes of interest were identified through the Danish National Patient Register.

RESULTS: Women with occupational exposure to animals had significantly higher IgG antibody concentrations against Campylobacter, Salmonella, and Yersinia, whereas they had lower concentrations of IgM and IgA antibodies.

CONCLUSIONS: Serological markers were not identified as risk factors for adverse pregnancy outcomes, with the exception of elevated concentrations of Salmonella antibodies, which were found to be associated with an increased risk of preterm birth.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Volume28
Pages (from-to)74-9
Number of pages6
ISSN1201-9712
DOIs
Publication statusPublished - Nov 2014

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