Calprotectin - A novel marker of obesity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Ole Hartvig Mortensen
  • Anders Rinnov Nielsen, The Centre of Inflammation and Metabolism, University of Copenhagen
  • ,
  • Christian Erikstrup
  • Peter Plomgaard, University of Copenhagen
  • ,
  • Christian Philip Fischer, The Centre of Inflammation and Metabolism, University of Copenhagen
  • ,
  • Rikke Krogh-Madsen, University of Copenhagen
  • ,
  • Birgitte Lindegaard, University of Copenhagen
  • ,
  • Anne Marie Petersen, The Centre of Inflammation and Metabolism, University of Copenhagen
  • ,
  • Sarah Taudorf, University of Copenhagen
  • ,
  • Christian Philip, University of Copenhagen

Background: The two inflammatory molecules, S100A8 and S100A9, form a heterodimer, calprotectin. Plasma calprotectin levels are elevated in various inflammatory disorders. We hypothesized that plasma calprotectin levels would be increased in subjects with low-grade systemic inflammation i.e. either obese subjects or subjects with type 2 diabetes. Methodology/Principal Findings: Plasma calprotectin and skeletal muscle S100A8 mRNA levels were measured in a cohort consisting of 199 subjects divided into four groups depending on presence or absence of type 2 diabetes (T2D), and presence or absence of obesity. There was a significant interaction between obesity and T2D (p = 0.012). Plasma calprotectin was increased in obese relative to non-obese controls (p<0.0001), whereas it did not differ between obese and non-obese patients with T2D (p=0.62). S100A8 mRNA levels in skeletal muscle were not influenced by obesity or T2D. Multivariate regression analysis (adjusting for age, sex, smoking and HOMA2-IR) showed plasma calprotectin to be strongly associated with BMI, even when further adjusted for fitness, CRP, TNF-α or neutrophil number. Conclusions/Significance: Plasma calprotectin is a marker of obesity in individuals without type 2 diabetes.

Original languageEnglish
Article numbere7419
JournalPLOS ONE
Volume4
Issue10
ISSN1932-6203
DOIs
Publication statusPublished - 12 Oct 2009
Externally publishedYes

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