C3dg Quantification by PEG Precipitation and or TRIFMA

Anne Troldborg*, Jens Christian Jensenius

*Corresponding author for this work

Research output: Contribution to book/anthology/report/proceedingBook chapterCommunication

Abstract

Detection of complement activation products can be carried out in a number of ways, and different methods are used in different laboratories. No international standard for measuring complement activation in the clinical setting has been agreed upon.Here we describe a modified assay for measuring C3dg. The assay is simple, inexpensive and stable. The estimation of C3dg directly reflects complement turnover independently of activation pathway.

Original languageEnglish
Title of host publicationMethods in Molecular Biology : Innovative Diagnostic and Research Protocols
EditorsLubka T. Roumenina
Number of pages7
Place of publication New York
PublisherSpringer
Publication date2021
Pages43-49
ISBN (Print)978-1-0716-1015-2
ISBN (Electronic)978-1-0716-1016-9
DOIs
Publication statusPublished - 2021
SeriesMethods in Molecular Biology
Volume2227
ISSN1064-3745

Keywords

  • Complement activation
  • Complement protein C3dg
  • Complement system
  • ELISA
  • TRIFMA

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