C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients. / Jørgensen, Kaj; Povlsen, Johan; Madsen, Søren; Madsen, Melvin; Hansen, Hans; Pedersen, Asger Roer; Heinsvig, Else-Marie; Poulsen, Jørgen.

In: Nephrology, Dialysis, Transplantation, Vol. 17, No. 8, 2002, p. 1487-90.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Jørgensen, K, Povlsen, J, Madsen, S, Madsen, M, Hansen, H, Pedersen, AR, Heinsvig, E-M & Poulsen, J 2002, 'C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients.', Nephrology, Dialysis, Transplantation, vol. 17, no. 8, pp. 1487-90.

APA

Jørgensen, K., Povlsen, J., Madsen, S., Madsen, M., Hansen, H., Pedersen, A. R., Heinsvig, E-M., & Poulsen, J. (2002). C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients. Nephrology, Dialysis, Transplantation, 17(8), 1487-90.

CBE

Jørgensen K, Povlsen J, Madsen S, Madsen M, Hansen H, Pedersen AR, Heinsvig E-M, Poulsen J. 2002. C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients. Nephrology, Dialysis, Transplantation. 17(8):1487-90.

MLA

Vancouver

Author

Jørgensen, Kaj ; Povlsen, Johan ; Madsen, Søren ; Madsen, Melvin ; Hansen, Hans ; Pedersen, Asger Roer ; Heinsvig, Else-Marie ; Poulsen, Jørgen. / C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients. In: Nephrology, Dialysis, Transplantation. 2002 ; Vol. 17, No. 8. pp. 1487-90.

Bibtex

@article{f4b16dc0db4411dc9e31000ea68e967b,
title = "C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients.",
abstract = "BACKGROUND: Recently, 2-h samples (C2) have been found superior to trough levels for therapeutic monitoring of transplanted patients receiving cyclosporin. The present study was undertaken to see if the same was the case for tacrolimus. METHODS: Blood tacrolimus levels were determined in 21 consecutive patients at 3 and 14 days after renal transplantation, and before and 1, 2, 3, 4, and 6 h after oral intake of 0.1 mg/kg tacrolimus. The area under the blood concentration/time curve (AUC) was determined by the trapezoidal method, association between blood concentration at each sampling time and AUC by Pearson's correlation coefficient, and pairs of correlation coefficients were compared by an asymptotic Wald-type test. RESULTS: AUC varied five-fold despite near-equal dosing. Pearson's correlation coefficient for trough level, 1, 2, 3, 4, and 6 h were 0.84, 0.60, 0.81, 0.95, 0.95, and 0.94 on day 3 and 0.94, 0.69, 0.92, 0.96, 0.94, 0.92 on day 14. Three-, 4- and 6-h levels had significantly higher correlation coefficients compared to trough, 1- and 2-h levels. One-hour samples had significantly lower correlation coefficients compared to all other sampling times on day 14. The patient with the highest AUC developed nephrotoxicity despite trough levels in the desired range. CONCLUSIONS: Two-hour levels are not superior to trough levels in tacrolimus-treated renal transplant patients. Despite good correlation between trough level and AUC, some patients may still receive nephrotoxic doses despite trough levels in the desired range. Sampling 3-6 h after oral intake may be at least as good as trough levels. Udgivelsesdato: 2002-Aug",
keywords = "Area Under Curve, Fasting, Humans, Immunosuppressive Agents, Kidney Transplantation, Postoperative Period, Prospective Studies, Reproducibility of Results, Tacrolimus, Time Factors",
author = "Kaj J{\o}rgensen and Johan Povlsen and S{\o}ren Madsen and Melvin Madsen and Hans Hansen and Pedersen, {Asger Roer} and Else-Marie Heinsvig and J{\o}rgen Poulsen",
year = "2002",
language = "English",
volume = "17",
pages = "1487--90",
journal = "Nephrology, Dialysis, Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients.

AU - Jørgensen, Kaj

AU - Povlsen, Johan

AU - Madsen, Søren

AU - Madsen, Melvin

AU - Hansen, Hans

AU - Pedersen, Asger Roer

AU - Heinsvig, Else-Marie

AU - Poulsen, Jørgen

PY - 2002

Y1 - 2002

N2 - BACKGROUND: Recently, 2-h samples (C2) have been found superior to trough levels for therapeutic monitoring of transplanted patients receiving cyclosporin. The present study was undertaken to see if the same was the case for tacrolimus. METHODS: Blood tacrolimus levels were determined in 21 consecutive patients at 3 and 14 days after renal transplantation, and before and 1, 2, 3, 4, and 6 h after oral intake of 0.1 mg/kg tacrolimus. The area under the blood concentration/time curve (AUC) was determined by the trapezoidal method, association between blood concentration at each sampling time and AUC by Pearson's correlation coefficient, and pairs of correlation coefficients were compared by an asymptotic Wald-type test. RESULTS: AUC varied five-fold despite near-equal dosing. Pearson's correlation coefficient for trough level, 1, 2, 3, 4, and 6 h were 0.84, 0.60, 0.81, 0.95, 0.95, and 0.94 on day 3 and 0.94, 0.69, 0.92, 0.96, 0.94, 0.92 on day 14. Three-, 4- and 6-h levels had significantly higher correlation coefficients compared to trough, 1- and 2-h levels. One-hour samples had significantly lower correlation coefficients compared to all other sampling times on day 14. The patient with the highest AUC developed nephrotoxicity despite trough levels in the desired range. CONCLUSIONS: Two-hour levels are not superior to trough levels in tacrolimus-treated renal transplant patients. Despite good correlation between trough level and AUC, some patients may still receive nephrotoxic doses despite trough levels in the desired range. Sampling 3-6 h after oral intake may be at least as good as trough levels. Udgivelsesdato: 2002-Aug

AB - BACKGROUND: Recently, 2-h samples (C2) have been found superior to trough levels for therapeutic monitoring of transplanted patients receiving cyclosporin. The present study was undertaken to see if the same was the case for tacrolimus. METHODS: Blood tacrolimus levels were determined in 21 consecutive patients at 3 and 14 days after renal transplantation, and before and 1, 2, 3, 4, and 6 h after oral intake of 0.1 mg/kg tacrolimus. The area under the blood concentration/time curve (AUC) was determined by the trapezoidal method, association between blood concentration at each sampling time and AUC by Pearson's correlation coefficient, and pairs of correlation coefficients were compared by an asymptotic Wald-type test. RESULTS: AUC varied five-fold despite near-equal dosing. Pearson's correlation coefficient for trough level, 1, 2, 3, 4, and 6 h were 0.84, 0.60, 0.81, 0.95, 0.95, and 0.94 on day 3 and 0.94, 0.69, 0.92, 0.96, 0.94, 0.92 on day 14. Three-, 4- and 6-h levels had significantly higher correlation coefficients compared to trough, 1- and 2-h levels. One-hour samples had significantly lower correlation coefficients compared to all other sampling times on day 14. The patient with the highest AUC developed nephrotoxicity despite trough levels in the desired range. CONCLUSIONS: Two-hour levels are not superior to trough levels in tacrolimus-treated renal transplant patients. Despite good correlation between trough level and AUC, some patients may still receive nephrotoxic doses despite trough levels in the desired range. Sampling 3-6 h after oral intake may be at least as good as trough levels. Udgivelsesdato: 2002-Aug

KW - Area Under Curve

KW - Fasting

KW - Humans

KW - Immunosuppressive Agents

KW - Kidney Transplantation

KW - Postoperative Period

KW - Prospective Studies

KW - Reproducibility of Results

KW - Tacrolimus

KW - Time Factors

M3 - Journal article

C2 - 12147799

VL - 17

SP - 1487

EP - 1490

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

SN - 0931-0509

IS - 8

ER -