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Brief Report: Cesarean Delivery and Subsequent Fecundability

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  • Rose G Radin, From the aDepartment of Epidemiology, Boston University School of Public Health, Boston, MA; bEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute for Child Health and Human Development, Bethesda, MD; cDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; dRTI Health Solutions, Research Triangle Park, NC; and eDepartment of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA.
  • ,
  • Ellen M Mikkelsen
  • Kenneth J Rothman
  • ,
  • Elizabeth E Hatch
  • ,
  • Henrik T Sorensen
  • Anders H Riis
  • Wendy Kuohung
  • ,
  • Lauren A Wise

BACKGROUND: Studies have shown that cesarean delivery is associated with fewer subsequent births relative to vaginal delivery, but it is unclear whether confounding by pregnancy intention or indication for surgery explained these results. We evaluated the association between cesarean delivery and subsequent fecundability among 910 primiparous women after singleton live birth.

METHODS: In a cohort of Danish women planning pregnancy (2007-2012), obstetrical history was obtained via registry linkage; time-to-pregnancy and covariate data were collected via questionnaire. Fecundability ratios (FRs) and 95% confidence intervals (CIs) were adjusted for potential confounders.

RESULTS: Relative to spontaneous vaginal delivery, emergency cesarean delivery with cephalic presentation showed little association with fecundability (FR = 1.0, 95% CI = 0.83, 1.3), but cesarean delivery with breech presentation (FR = 0.72, 95% CI = 0.53, 0.97) and planned cesarean delivery with cephalic presentation (FR = 0.51, 95% CI = 0.25, 1.0) were associated with reduced fecundability.

CONCLUSIONS: The cesarean-fecundability association varied by previous fetal presentation and emergency status.

Original languageEnglish
JournalEpidemiology
Volume27
Issue6
Pages (from-to)889-93
Number of pages5
ISSN1044-3983
DOIs
Publication statusPublished - Nov 2016

    Research areas

  • Journal Article

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