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Breast cancer recurrence after reoperation for surgical bleeding

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Breast cancer recurrence after reoperation for surgical bleeding. / Pedersen, Rikke Nørgaard; Bhaskaran, K; Heide-Jørgensen, U; Nørgaard, Mette; Christiansen, P M; Kroman, N; Sørensen, Henrik Toft; Cronin-Fenton, D P.

In: British Journal of Surgery, Vol. 104, No. 12, 11.2017, p. 1665-1674.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Pedersen, Rikke Nørgaard et al. "Breast cancer recurrence after reoperation for surgical bleeding". British Journal of Surgery. 2017, 104(12). 1665-1674. https://doi.org/10.1002/bjs.10592

Vancouver

Pedersen RN, Bhaskaran K, Heide-Jørgensen U, Nørgaard M, Christiansen PM, Kroman N et al. Breast cancer recurrence after reoperation for surgical bleeding. British Journal of Surgery. 2017 Nov;104(12):1665-1674. https://doi.org/10.1002/bjs.10592

Author

Pedersen, Rikke Nørgaard ; Bhaskaran, K ; Heide-Jørgensen, U ; Nørgaard, Mette ; Christiansen, P M ; Kroman, N ; Sørensen, Henrik Toft ; Cronin-Fenton, D P. / Breast cancer recurrence after reoperation for surgical bleeding. In: British Journal of Surgery. 2017 ; Vol. 104, No. 12. pp. 1665-1674.

Bibtex

@article{9622c292b1a14f73845ad11bbf0e4e80,
title = "Breast cancer recurrence after reoperation for surgical bleeding",
abstract = "BACKGROUND: Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.METHODS: Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified. Information on reoperation for bleeding within 14 days of the primary surgery was retrieved from the DNPR. Follow-up began 14 days after primary surgery and continued until breast cancer recurrence, death, emigration, 10 years of follow-up, or 1 January 2013. Incidence rates of breast cancer recurrence were calculated and Cox regression models were used to quantify the association between reoperation and recurrence, adjusting for potential confounders. Crude and adjusted hazard ratios according to site of recurrence were calculated.RESULTS: Among 30 711 patients (205 926 person-years of follow-up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow-up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person-years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person-years for non-reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.CONCLUSION: In this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.",
keywords = "Adult, Aged, Aged, 80 and over, Breast Neoplasms, Denmark, Female, Follow-Up Studies, Humans, Incidence, Mastectomy, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Postoperative Hemorrhage, Registries, Reoperation, Risk Factors, Journal Article",
author = "Pedersen, {Rikke N{\o}rgaard} and K Bhaskaran and U Heide-J{\o}rgensen and Mette N{\o}rgaard and Christiansen, {P M} and N Kroman and S{\o}rensen, {Henrik Toft} and Cronin-Fenton, {D P}",
note = "{\textcopyright} 2017 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.",
year = "2017",
month = nov,
doi = "10.1002/bjs.10592",
language = "English",
volume = "104",
pages = "1665--1674",
journal = "British Journal of Surgery",
issn = "0007-1323",
publisher = "JohnWiley & Sons Ltd.",
number = "12",

}

RIS

TY - JOUR

T1 - Breast cancer recurrence after reoperation for surgical bleeding

AU - Pedersen, Rikke Nørgaard

AU - Bhaskaran, K

AU - Heide-Jørgensen, U

AU - Nørgaard, Mette

AU - Christiansen, P M

AU - Kroman, N

AU - Sørensen, Henrik Toft

AU - Cronin-Fenton, D P

N1 - © 2017 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.

PY - 2017/11

Y1 - 2017/11

N2 - BACKGROUND: Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.METHODS: Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified. Information on reoperation for bleeding within 14 days of the primary surgery was retrieved from the DNPR. Follow-up began 14 days after primary surgery and continued until breast cancer recurrence, death, emigration, 10 years of follow-up, or 1 January 2013. Incidence rates of breast cancer recurrence were calculated and Cox regression models were used to quantify the association between reoperation and recurrence, adjusting for potential confounders. Crude and adjusted hazard ratios according to site of recurrence were calculated.RESULTS: Among 30 711 patients (205 926 person-years of follow-up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow-up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person-years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person-years for non-reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.CONCLUSION: In this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.

AB - BACKGROUND: Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.METHODS: Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified. Information on reoperation for bleeding within 14 days of the primary surgery was retrieved from the DNPR. Follow-up began 14 days after primary surgery and continued until breast cancer recurrence, death, emigration, 10 years of follow-up, or 1 January 2013. Incidence rates of breast cancer recurrence were calculated and Cox regression models were used to quantify the association between reoperation and recurrence, adjusting for potential confounders. Crude and adjusted hazard ratios according to site of recurrence were calculated.RESULTS: Among 30 711 patients (205 926 person-years of follow-up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow-up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person-years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person-years for non-reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.CONCLUSION: In this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Mastectomy

KW - Mastectomy, Segmental

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Postoperative Hemorrhage

KW - Registries

KW - Reoperation

KW - Risk Factors

KW - Journal Article

U2 - 10.1002/bjs.10592

DO - 10.1002/bjs.10592

M3 - Journal article

C2 - 28782800

VL - 104

SP - 1665

EP - 1674

JO - British Journal of Surgery

JF - British Journal of Surgery

SN - 0007-1323

IS - 12

ER -