Breakdown of Whole-brain Dynamics in Preterm-born Children

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DOI

  • Nelly Padilla, Karolinska Institutet
  • ,
  • Victor M. Saenger, Pompeu Fabra University
  • ,
  • Tim J. van Hartevelt, University of Oxford
  • ,
  • Henrique M. Fernandes
  • Finn Lennartsson, Karolinska Institutet, Lund University
  • ,
  • Jesper L.R. Andersson, University of Oxford, Oxford
  • ,
  • Morten Kringelbach
  • Gustavo Deco, Pompeu Fabra University, ICREA, Max Planck Institute for Human Cognitive and Brain Sciences, Monash University
  • ,
  • Ulrika Åden, Karolinska Institutet, Karolinska University Hospital, Stockholm

The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at < 27 weeks of gestation and 28 full-term controls. Two approaches were adopted in both groups, when they were 10 years of age, using structural and functional brain magnetic resonance imaging data. The first was using a novel intrinsic ignition analysis to study the ability of the areas of the brain to propagate neural activity. The second was a whole-brain Hopf model, to define the level of stability, desynchronization, or criticality of the brain. EPT-born children exhibited fewer intrinsic ignition events than controls; nodes were related to less sophisticated aspects of cognitive control, and there was a different hierarchy pattern in the propagation of information and suboptimal synchronicity and criticality. The largest differences were found in brain nodes belonging to the rich-club architecture. These results provide important insights into the neural substrates underlying brain reorganization and neurodevelopmental impairments related to prematurity.

Original languageEnglish
JournalCerebral Cortex
Volume30
Issue3
Pages (from-to)1159-1170
Number of pages12
ISSN1047-3211
DOIs
Publication statusPublished - 2020

    Research areas

  • brain development, brain dynamics, functional connectivity, neurodevelopment, prematurity

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