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Brain capillary pericytes and neurovascular coupling

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  • Søren Grubb, University of Copenhagen
  • ,
  • Martin Lauritzen, University of Copenhagen, Rigshospitalet
  • ,
  • Christian Aalkjær

The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.

Original languageEnglish
Article number110893
JournalComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
Volume254
Number of pages7
ISSN1095-6433
DOIs
Publication statusPublished - Apr 2021

    Research areas

  • Arterioles smooth muscle neuron astrocyte sphincter

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