Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: A systematic review and meta-analysis

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Bone tissue engineering in oral peri-implant defects in preclinical in vivo research : A systematic review and meta-analysis. / Shanbhag, Siddharth; Pandis, Nikolaos; Mustafa, Kamal et al.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 12, No. 1, 01.2018, p. e336-e349.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Shanbhag, S, Pandis, N, Mustafa, K, Nyengaard, JR & Stavropoulos, A 2018, 'Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: A systematic review and meta-analysis', Journal of Tissue Engineering and Regenerative Medicine, vol. 12, no. 1, pp. e336-e349. https://doi.org/10.1002/term.2412

APA

Shanbhag, S., Pandis, N., Mustafa, K., Nyengaard, J. R., & Stavropoulos, A. (2018). Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: A systematic review and meta-analysis. Journal of Tissue Engineering and Regenerative Medicine, 12(1), e336-e349. https://doi.org/10.1002/term.2412

CBE

Shanbhag S, Pandis N, Mustafa K, Nyengaard JR, Stavropoulos A. 2018. Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: A systematic review and meta-analysis. Journal of Tissue Engineering and Regenerative Medicine. 12(1):e336-e349. https://doi.org/10.1002/term.2412

MLA

Shanbhag, Siddharth et al. "Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: A systematic review and meta-analysis". Journal of Tissue Engineering and Regenerative Medicine. 2018, 12(1). e336-e349. https://doi.org/10.1002/term.2412

Vancouver

Shanbhag S, Pandis N, Mustafa K, Nyengaard JR, Stavropoulos A. Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: A systematic review and meta-analysis. Journal of Tissue Engineering and Regenerative Medicine. 2018 Jan;12(1):e336-e349. https://doi.org/10.1002/term.2412

Author

Shanbhag, Siddharth ; Pandis, Nikolaos ; Mustafa, Kamal et al. / Bone tissue engineering in oral peri-implant defects in preclinical in vivo research : A systematic review and meta-analysis. In: Journal of Tissue Engineering and Regenerative Medicine. 2018 ; Vol. 12, No. 1. pp. e336-e349.

Bibtex

@article{7926180c600d455d86a672c9dfee0ea7,
title = "Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: A systematic review and meta-analysis",
abstract = "The regeneration and establishment of osseointegration within oral peri-implant bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous and/or biomaterial-based bone grafting. The objective of this systematic review was to answer the focused question: in animal models, do cell-based BTE strategies enhance bone regeneration and/or implant osseointegration in experimental peri-implant defects, compared with grafting with autogenous bone or only biomaterial scaffolds? Electronic databases were searched for controlled animal studies reporting on peri-implant defects and implantation of mesenchymal stem cells (MSC) or other cells seeded on biomaterial scaffolds, following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Random effects meta-analyses were performed for the outcomes histomorphometric bone area fraction (BA) and bone-to-implant contact (BIC). Nineteen studies reporting on large animal models (dogs and sheep) were included. Experimental defects were created surgically (16 studies) or via ligature-induced peri-implantitis (LIPI, three studies). In general, studies presented with an unclear to high risk of bias. In most studies, MSC were used in combination with alloplastic mineral phase or polymer scaffolds; no study directly compared cell-loaded scaffolds vs. autogenous bone. In three studies, cells were also modified by ex vivo gene transfer of osteoinductive factors. The meta-analyses indicated statistically significant benefits in favour of: (a) cell-loaded vs. cell-free scaffolds [weighted mean differences (WMD) of 10.73–12.30% BA and 11.77–15.15% BIC] in canine surgical defect and LIPI models; and (b) gene-modified vs. unmodified cells (WMD of 29.44% BA and 16.50% BIC) in canine LIPI models. Overall, heterogeneity in the meta-analyses was high (I2 70–88%); considerable variation was observed among studies regarding the nature of cells and scaffolds used. In summary, bone regeneration and osseointegration in peri-implant defects are enhanced by the addition of osteogenic cells to biomaterial scaffolds. Although the direction of treatment outcome is clearly in favour of BTE strategies, due to the limited magnitude of treatment effect observed, no conclusive statements regarding the clinical benefit of such procedures for oral indications can yet be made.",
keywords = "bone tissue engineering, dental implants, mesenchymal stem cells, meta-analysis, osseointegration, scaffolds",
author = "Siddharth Shanbhag and Nikolaos Pandis and Kamal Mustafa and Nyengaard, {Jens R.} and Andreas Stavropoulos",
year = "2018",
month = jan,
doi = "10.1002/term.2412",
language = "English",
volume = "12",
pages = "e336--e349",
journal = "Journal of Tissue Engineering and Regenerative Medicine",
issn = "1932-6254",
publisher = "JohnWiley & Sons, Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Bone tissue engineering in oral peri-implant defects in preclinical in vivo research

T2 - A systematic review and meta-analysis

AU - Shanbhag, Siddharth

AU - Pandis, Nikolaos

AU - Mustafa, Kamal

AU - Nyengaard, Jens R.

AU - Stavropoulos, Andreas

PY - 2018/1

Y1 - 2018/1

N2 - The regeneration and establishment of osseointegration within oral peri-implant bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous and/or biomaterial-based bone grafting. The objective of this systematic review was to answer the focused question: in animal models, do cell-based BTE strategies enhance bone regeneration and/or implant osseointegration in experimental peri-implant defects, compared with grafting with autogenous bone or only biomaterial scaffolds? Electronic databases were searched for controlled animal studies reporting on peri-implant defects and implantation of mesenchymal stem cells (MSC) or other cells seeded on biomaterial scaffolds, following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Random effects meta-analyses were performed for the outcomes histomorphometric bone area fraction (BA) and bone-to-implant contact (BIC). Nineteen studies reporting on large animal models (dogs and sheep) were included. Experimental defects were created surgically (16 studies) or via ligature-induced peri-implantitis (LIPI, three studies). In general, studies presented with an unclear to high risk of bias. In most studies, MSC were used in combination with alloplastic mineral phase or polymer scaffolds; no study directly compared cell-loaded scaffolds vs. autogenous bone. In three studies, cells were also modified by ex vivo gene transfer of osteoinductive factors. The meta-analyses indicated statistically significant benefits in favour of: (a) cell-loaded vs. cell-free scaffolds [weighted mean differences (WMD) of 10.73–12.30% BA and 11.77–15.15% BIC] in canine surgical defect and LIPI models; and (b) gene-modified vs. unmodified cells (WMD of 29.44% BA and 16.50% BIC) in canine LIPI models. Overall, heterogeneity in the meta-analyses was high (I2 70–88%); considerable variation was observed among studies regarding the nature of cells and scaffolds used. In summary, bone regeneration and osseointegration in peri-implant defects are enhanced by the addition of osteogenic cells to biomaterial scaffolds. Although the direction of treatment outcome is clearly in favour of BTE strategies, due to the limited magnitude of treatment effect observed, no conclusive statements regarding the clinical benefit of such procedures for oral indications can yet be made.

AB - The regeneration and establishment of osseointegration within oral peri-implant bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous and/or biomaterial-based bone grafting. The objective of this systematic review was to answer the focused question: in animal models, do cell-based BTE strategies enhance bone regeneration and/or implant osseointegration in experimental peri-implant defects, compared with grafting with autogenous bone or only biomaterial scaffolds? Electronic databases were searched for controlled animal studies reporting on peri-implant defects and implantation of mesenchymal stem cells (MSC) or other cells seeded on biomaterial scaffolds, following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Random effects meta-analyses were performed for the outcomes histomorphometric bone area fraction (BA) and bone-to-implant contact (BIC). Nineteen studies reporting on large animal models (dogs and sheep) were included. Experimental defects were created surgically (16 studies) or via ligature-induced peri-implantitis (LIPI, three studies). In general, studies presented with an unclear to high risk of bias. In most studies, MSC were used in combination with alloplastic mineral phase or polymer scaffolds; no study directly compared cell-loaded scaffolds vs. autogenous bone. In three studies, cells were also modified by ex vivo gene transfer of osteoinductive factors. The meta-analyses indicated statistically significant benefits in favour of: (a) cell-loaded vs. cell-free scaffolds [weighted mean differences (WMD) of 10.73–12.30% BA and 11.77–15.15% BIC] in canine surgical defect and LIPI models; and (b) gene-modified vs. unmodified cells (WMD of 29.44% BA and 16.50% BIC) in canine LIPI models. Overall, heterogeneity in the meta-analyses was high (I2 70–88%); considerable variation was observed among studies regarding the nature of cells and scaffolds used. In summary, bone regeneration and osseointegration in peri-implant defects are enhanced by the addition of osteogenic cells to biomaterial scaffolds. Although the direction of treatment outcome is clearly in favour of BTE strategies, due to the limited magnitude of treatment effect observed, no conclusive statements regarding the clinical benefit of such procedures for oral indications can yet be made.

KW - bone tissue engineering

KW - dental implants

KW - mesenchymal stem cells

KW - meta-analysis

KW - osseointegration

KW - scaffolds

UR - http://www.scopus.com/inward/record.url?scp=85019984882&partnerID=8YFLogxK

U2 - 10.1002/term.2412

DO - 10.1002/term.2412

M3 - Review

C2 - 28095650

AN - SCOPUS:85019984882

VL - 12

SP - e336-e349

JO - Journal of Tissue Engineering and Regenerative Medicine

JF - Journal of Tissue Engineering and Regenerative Medicine

SN - 1932-6254

IS - 1

ER -