Bone mineral density changes in a free vascularised fibular graft in the distal femoral bone after osteosarcoma in a 10-year-old boy: a 7-year follow-up

TY - JOUR

T1 - Bone mineral density changes in a free vascularised fibular graft in the distal femoral bone after osteosarcoma in a 10-year-old boy

T2 - a 7-year follow-up

AU - Jørgensen, Andrea René

AU - Jørgensen, Peter Holmberg

AU - Jul Kiil, Birgitte

AU - Stilling, Maiken

N1 - © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/3

Y1 - 2021/3

N2 - A 10-year-old boy presented with continuous reports of pain located to the left knee. Imaging revealed a sclerotic process in the left distal femur, and biopsies were consistent with chondroblastic osteosarcoma. As part of standard treatment the patient underwent neoadjuvant chemotherapy followed by limb sparring surgery and adjuvant chemotherapy. The entire tumour was excised and femoral bone reconstruction was performed with a double barrel free vascularised fibular graft. Bone mineral density (BMD) can be decreased in childhood survivors of cancer. The patient was followed for 7 years with dual-energy X-ray absorptiometry scans in order to assess BMD and graft adaption. Despite two accidental fractures to the graft region local and global BMD underwent an overall increase. Approximately 7 years after tumour resection the patient had a global Z-score of 0.2, which is considered within normal range.

AB - A 10-year-old boy presented with continuous reports of pain located to the left knee. Imaging revealed a sclerotic process in the left distal femur, and biopsies were consistent with chondroblastic osteosarcoma. As part of standard treatment the patient underwent neoadjuvant chemotherapy followed by limb sparring surgery and adjuvant chemotherapy. The entire tumour was excised and femoral bone reconstruction was performed with a double barrel free vascularised fibular graft. Bone mineral density (BMD) can be decreased in childhood survivors of cancer. The patient was followed for 7 years with dual-energy X-ray absorptiometry scans in order to assess BMD and graft adaption. Despite two accidental fractures to the graft region local and global BMD underwent an overall increase. Approximately 7 years after tumour resection the patient had a global Z-score of 0.2, which is considered within normal range.

KW - cancer intervention

KW - orthopaedics

KW - osteoporosis

KW - paediatric oncology

UR - http://www.scopus.com/inward/record.url?scp=85103491025&partnerID=8YFLogxK

U2 - 10.1136/bcr-2020-236097

DO - 10.1136/bcr-2020-236097

M3 - Journal article

C2 - 33762269

SN - 1757-790X

VL - 14

JO - BMJ Case Reports

JF - BMJ Case Reports

IS - 3

M1 - e236097

ER -