Bone Biomineral Properties Vary across Human Osteonal Bone

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Bone Biomineral Properties Vary across Human Osteonal Bone. / Wittig, Nina K.; Palle, Jonas; Østergaard, Maja; Frølich, Simon; Birkbak, Mie E.; Spiers, Kathryn M.; Garrevoet, Jan; Birkedal, Henrik.

In: ACS Nano, Vol. 13, No. 11, 11.2019, p. 12949-12956.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Wittig, NK, Palle, J, Østergaard, M, Frølich, S, Birkbak, ME, Spiers, KM, Garrevoet, J & Birkedal, H 2019, 'Bone Biomineral Properties Vary across Human Osteonal Bone', ACS Nano, vol. 13, no. 11, pp. 12949-12956. https://doi.org/10.1021/acsnano.9b05535

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Author

Wittig, Nina K. ; Palle, Jonas ; Østergaard, Maja ; Frølich, Simon ; Birkbak, Mie E. ; Spiers, Kathryn M. ; Garrevoet, Jan ; Birkedal, Henrik. / Bone Biomineral Properties Vary across Human Osteonal Bone. In: ACS Nano. 2019 ; Vol. 13, No. 11. pp. 12949-12956.

Bibtex

@article{a0de582f0227418091806210e2e738fc,
title = "Bone Biomineral Properties Vary across Human Osteonal Bone",
abstract = "The biomineralization of bone remains a puzzle. During Haversian remodeling in the dense human cortical bone, osteoclasts excavate a tunnel that is then filled in by osteoblasts with layers of bone of varying fibril orientations, resulting in a lamellar motif. Such bone represents an excellent possibility to increase our understanding of bone as a material as well as bone biomineralization by studying spatio/temporal variations in the biomineral across an osteon. To this end, fluorescence computed tomography and diffraction scattering computed tomography with sub-micrometer resolution is applied to obtain position resolved fluorescence spectra and diffraction patterns in a 3D volume. The microstructural properties of the apatite biomineral are not homogeneous but depend critically on the time point at which it was laid down. This indicates that the nature of bone biomineral is highly dependent on the microenvironment during bone formation and remodeling.",
keywords = "biomineralization, bone, diffraction scattering computed tomography, fluorescence computed tomography, hierarchical materials",
author = "Wittig, {Nina K.} and Jonas Palle and Maja {\O}stergaard and Simon Fr{\o}lich and Birkbak, {Mie E.} and Spiers, {Kathryn M.} and Jan Garrevoet and Henrik Birkedal",
year = "2019",
month = nov,
doi = "10.1021/acsnano.9b05535",
language = "English",
volume = "13",
pages = "12949--12956",
journal = "A C S Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "11",

}

RIS

TY - JOUR

T1 - Bone Biomineral Properties Vary across Human Osteonal Bone

AU - Wittig, Nina K.

AU - Palle, Jonas

AU - Østergaard, Maja

AU - Frølich, Simon

AU - Birkbak, Mie E.

AU - Spiers, Kathryn M.

AU - Garrevoet, Jan

AU - Birkedal, Henrik

PY - 2019/11

Y1 - 2019/11

N2 - The biomineralization of bone remains a puzzle. During Haversian remodeling in the dense human cortical bone, osteoclasts excavate a tunnel that is then filled in by osteoblasts with layers of bone of varying fibril orientations, resulting in a lamellar motif. Such bone represents an excellent possibility to increase our understanding of bone as a material as well as bone biomineralization by studying spatio/temporal variations in the biomineral across an osteon. To this end, fluorescence computed tomography and diffraction scattering computed tomography with sub-micrometer resolution is applied to obtain position resolved fluorescence spectra and diffraction patterns in a 3D volume. The microstructural properties of the apatite biomineral are not homogeneous but depend critically on the time point at which it was laid down. This indicates that the nature of bone biomineral is highly dependent on the microenvironment during bone formation and remodeling.

AB - The biomineralization of bone remains a puzzle. During Haversian remodeling in the dense human cortical bone, osteoclasts excavate a tunnel that is then filled in by osteoblasts with layers of bone of varying fibril orientations, resulting in a lamellar motif. Such bone represents an excellent possibility to increase our understanding of bone as a material as well as bone biomineralization by studying spatio/temporal variations in the biomineral across an osteon. To this end, fluorescence computed tomography and diffraction scattering computed tomography with sub-micrometer resolution is applied to obtain position resolved fluorescence spectra and diffraction patterns in a 3D volume. The microstructural properties of the apatite biomineral are not homogeneous but depend critically on the time point at which it was laid down. This indicates that the nature of bone biomineral is highly dependent on the microenvironment during bone formation and remodeling.

KW - biomineralization

KW - bone

KW - diffraction scattering computed tomography

KW - fluorescence computed tomography

KW - hierarchical materials

UR - http://www.scopus.com/inward/record.url?scp=85073827010&partnerID=8YFLogxK

U2 - 10.1021/acsnano.9b05535

DO - 10.1021/acsnano.9b05535

M3 - Journal article

C2 - 31613594

AN - SCOPUS:85073827010

VL - 13

SP - 12949

EP - 12956

JO - A C S Nano

JF - A C S Nano

SN - 1936-0851

IS - 11

ER -