Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis

Anna Kaisa Tuomi; Katariina Rebane; Ellen Dalen Arnstad; Lillemor Berntson; Anders Fasth; Mia Glerup; Troels Herlin; Hannu Kautiainen; Ellen Nordal; Suvi Peltoniemi; Marite Rygg; Veronika Rypdal; Marek Zak; Kristiina Aalto

doi:10.1186/s12969-023-00931-7

Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis

Anna Kaisa Tuomi^*, Katariina Rebane, Ellen Dalen Arnstad, Lillemor Berntson, Anders Fasth, Mia Glerup, Troels Herlin, Hannu Kautiainen, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Veronika Rypdal, Marek Zak, Kristiina Aalto

^*Corresponding author for this work

Department of Clinical Medicine - Department of Paediatrics

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Background: There is a growing interest concerning the relationship between obesity and several medical conditions and inflammation. Nevertheless, there is a lack of studies regarding body mass index (BMI) among patients with juvenile idiopathic arthritis (JIA). Our aim was to investigate the impact of BMI on health-related quality of life (HRQoL) measured with a 36-Item Short Form Survey (SF-36), disease activity, and disability in young adults with JIA. Methods: This study is a part of the population-based Nordic JIA cohort study. All newly diagnosed patients with JIA were recruited consecutively between 1997–2000 in specific regions in the Nordic countries. Patients in this sub-study were enrolled from 434 patients who attended their 18-year follow-up visit. Patients were classified according to the World Health Organization (WHO) into four groups based on their BMI. HRQoL, disease characteristics, disability, fatigue, sleep quality, physical activity, pain, comorbidities, and social status were assessed. Results: Three hundred fifty-five patients from the original study cohort were enrolled in this study and 72% of them were female. Mean age was 23.9 (± SD 4.4) years. A significant relationship was found between the JIA categories and BMI groups (p = 0.014). A significant relationship was also found between BMI and disease activity scores (DAS28) (p = 0.028), disability (p < 0.001), pain (p = 0.013), fatigue (p = 0.035), and sleep quality (p = 0.044). Moreover, a significant relationship between BMI and HRQoL regarding bodily pain (p = 0.010) and general health (p = 0.048) was revealed when adjusted for sex, age, and JIA subtype. Conclusion: We discovered that BMI was significantly related to HRQoL, disease activity, and disability. BMI deserves more attention considering the treatment options and outcome of JIA in young adults.

Original language	English
Article number	25
Journal	Pediatric Rheumatology
Volume	22
Issue	1
ISSN	1546-0096
DOIs	https://doi.org/10.1186/s12969-023-00931-7
Publication status	Published - Feb 2024

Keywords

Body mass index
Disability
Disease activity
Health-related quality of life
Juvenile idiopathic arthritis

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10.1186/s12969-023-00931-7Licence: CC0

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Tuomi, A. K., Rebane, K., Arnstad, E. D., Berntson, L., Fasth, A., Glerup, M., Herlin, T., Kautiainen, H., Nordal, E., Peltoniemi, S., Rygg, M., Rypdal, V., Zak, M., & Aalto, K. (2024). Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis. Pediatric Rheumatology , 22(1), Article 25. https://doi.org/10.1186/s12969-023-00931-7

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title = "Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis",

abstract = "Background: There is a growing interest concerning the relationship between obesity and several medical conditions and inflammation. Nevertheless, there is a lack of studies regarding body mass index (BMI) among patients with juvenile idiopathic arthritis (JIA). Our aim was to investigate the impact of BMI on health-related quality of life (HRQoL) measured with a 36-Item Short Form Survey (SF-36), disease activity, and disability in young adults with JIA. Methods: This study is a part of the population-based Nordic JIA cohort study. All newly diagnosed patients with JIA were recruited consecutively between 1997–2000 in specific regions in the Nordic countries. Patients in this sub-study were enrolled from 434 patients who attended their 18-year follow-up visit. Patients were classified according to the World Health Organization (WHO) into four groups based on their BMI. HRQoL, disease characteristics, disability, fatigue, sleep quality, physical activity, pain, comorbidities, and social status were assessed. Results: Three hundred fifty-five patients from the original study cohort were enrolled in this study and 72% of them were female. Mean age was 23.9 (± SD 4.4) years. A significant relationship was found between the JIA categories and BMI groups (p = 0.014). A significant relationship was also found between BMI and disease activity scores (DAS28) (p = 0.028), disability (p < 0.001), pain (p = 0.013), fatigue (p = 0.035), and sleep quality (p = 0.044). Moreover, a significant relationship between BMI and HRQoL regarding bodily pain (p = 0.010) and general health (p = 0.048) was revealed when adjusted for sex, age, and JIA subtype. Conclusion: We discovered that BMI was significantly related to HRQoL, disease activity, and disability. BMI deserves more attention considering the treatment options and outcome of JIA in young adults.",

keywords = "Body mass index, Disability, Disease activity, Health-related quality of life, Juvenile idiopathic arthritis",

author = "Tuomi, {Anna Kaisa} and Katariina Rebane and Arnstad, {Ellen Dalen} and Lillemor Berntson and Anders Fasth and Mia Glerup and Troels Herlin and Hannu Kautiainen and Ellen Nordal and Suvi Peltoniemi and Marite Rygg and Veronika Rypdal and Marek Zak and Kristiina Aalto",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = feb,

doi = "10.1186/s12969-023-00931-7",

language = "English",

volume = "22",

journal = "Pediatric Rheumatology ",

issn = "1546-0096",

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number = "1",

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Tuomi, AK, Rebane, K, Arnstad, ED, Berntson, L, Fasth, A, Glerup, M , Herlin, T, Kautiainen, H, Nordal, E, Peltoniemi, S, Rygg, M, Rypdal, V, Zak, M & Aalto, K 2024, 'Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis', Pediatric Rheumatology , vol. 22, no. 1, 25. https://doi.org/10.1186/s12969-023-00931-7

Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis. / Tuomi, Anna Kaisa; Rebane, Katariina; Arnstad, Ellen Dalen et al.
In: Pediatric Rheumatology , Vol. 22, No. 1, 25, 02.2024.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis

AU - Tuomi, Anna Kaisa

AU - Rebane, Katariina

AU - Arnstad, Ellen Dalen

AU - Berntson, Lillemor

AU - Fasth, Anders

AU - Glerup, Mia

AU - Herlin, Troels

AU - Kautiainen, Hannu

AU - Nordal, Ellen

AU - Peltoniemi, Suvi

AU - Rygg, Marite

AU - Rypdal, Veronika

AU - Zak, Marek

AU - Aalto, Kristiina

PY - 2024/2

Y1 - 2024/2

N2 - Background: There is a growing interest concerning the relationship between obesity and several medical conditions and inflammation. Nevertheless, there is a lack of studies regarding body mass index (BMI) among patients with juvenile idiopathic arthritis (JIA). Our aim was to investigate the impact of BMI on health-related quality of life (HRQoL) measured with a 36-Item Short Form Survey (SF-36), disease activity, and disability in young adults with JIA. Methods: This study is a part of the population-based Nordic JIA cohort study. All newly diagnosed patients with JIA were recruited consecutively between 1997–2000 in specific regions in the Nordic countries. Patients in this sub-study were enrolled from 434 patients who attended their 18-year follow-up visit. Patients were classified according to the World Health Organization (WHO) into four groups based on their BMI. HRQoL, disease characteristics, disability, fatigue, sleep quality, physical activity, pain, comorbidities, and social status were assessed. Results: Three hundred fifty-five patients from the original study cohort were enrolled in this study and 72% of them were female. Mean age was 23.9 (± SD 4.4) years. A significant relationship was found between the JIA categories and BMI groups (p = 0.014). A significant relationship was also found between BMI and disease activity scores (DAS28) (p = 0.028), disability (p < 0.001), pain (p = 0.013), fatigue (p = 0.035), and sleep quality (p = 0.044). Moreover, a significant relationship between BMI and HRQoL regarding bodily pain (p = 0.010) and general health (p = 0.048) was revealed when adjusted for sex, age, and JIA subtype. Conclusion: We discovered that BMI was significantly related to HRQoL, disease activity, and disability. BMI deserves more attention considering the treatment options and outcome of JIA in young adults.

AB - Background: There is a growing interest concerning the relationship between obesity and several medical conditions and inflammation. Nevertheless, there is a lack of studies regarding body mass index (BMI) among patients with juvenile idiopathic arthritis (JIA). Our aim was to investigate the impact of BMI on health-related quality of life (HRQoL) measured with a 36-Item Short Form Survey (SF-36), disease activity, and disability in young adults with JIA. Methods: This study is a part of the population-based Nordic JIA cohort study. All newly diagnosed patients with JIA were recruited consecutively between 1997–2000 in specific regions in the Nordic countries. Patients in this sub-study were enrolled from 434 patients who attended their 18-year follow-up visit. Patients were classified according to the World Health Organization (WHO) into four groups based on their BMI. HRQoL, disease characteristics, disability, fatigue, sleep quality, physical activity, pain, comorbidities, and social status were assessed. Results: Three hundred fifty-five patients from the original study cohort were enrolled in this study and 72% of them were female. Mean age was 23.9 (± SD 4.4) years. A significant relationship was found between the JIA categories and BMI groups (p = 0.014). A significant relationship was also found between BMI and disease activity scores (DAS28) (p = 0.028), disability (p < 0.001), pain (p = 0.013), fatigue (p = 0.035), and sleep quality (p = 0.044). Moreover, a significant relationship between BMI and HRQoL regarding bodily pain (p = 0.010) and general health (p = 0.048) was revealed when adjusted for sex, age, and JIA subtype. Conclusion: We discovered that BMI was significantly related to HRQoL, disease activity, and disability. BMI deserves more attention considering the treatment options and outcome of JIA in young adults.

KW - Body mass index

KW - Disability

KW - Disease activity

KW - Health-related quality of life

KW - Juvenile idiopathic arthritis

UR - http://www.scopus.com/inward/record.url?scp=85183818556&partnerID=8YFLogxK

U2 - 10.1186/s12969-023-00931-7

DO - 10.1186/s12969-023-00931-7

M3 - Journal article

C2 - 38308280

AN - SCOPUS:85183818556

SN - 1546-0096

VL - 22

JO - Pediatric Rheumatology

JF - Pediatric Rheumatology

IS - 1

M1 - 25

ER -

Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis

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Keywords

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