Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies

Emma Fontvieille; Vivian Viallon; Martina Recalde; Reynalda Cordova; Anna Jansana; Laia Peruchet-Noray; Hannah Lennon; Alicia K Heath; Dagfinn Aune; Sofia Christakoudi; Verena Katzke; Rudolf Kaaks; Elif Inan-Eroglu; Matthias B Schulze; Lene Mellemkjær; Anne Tjønneland; Kim Overvad; Marta Farràs; Dafina Petrova; Pilar Amiano; María-Dolores Chirlaque; Conchi Moreno-Iribas; Sandar Tin Tin; Giovanna Masala; Sabina Sieri; Fulvio Ricceri; Salvatore Panico; Anne M May; Evelyn M Monninkhof; Elisabete Weiderpass; Marc J Gunter; Pietro Ferrari; Heinz Freisling

doi:10.1186/s12916-023-03114-z

Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies

Emma Fontvieille, Vivian Viallon, Martina Recalde, Reynalda Cordova, Anna Jansana, Laia Peruchet-Noray, Hannah Lennon, Alicia K Heath, Dagfinn Aune, Sofia Christakoudi, Verena Katzke, Rudolf Kaaks, Elif Inan-Eroglu, Matthias B Schulze, Lene Mellemkjær, Anne Tjønneland, Kim Overvad, Marta Farràs, Dafina Petrova, Pilar AmianoMaría-Dolores Chirlaque, Conchi Moreno-Iribas, Sandar Tin Tin, Giovanna Masala, Sabina Sieri, Fulvio Ricceri, Salvatore Panico, Anne M May, Evelyn M Monninkhof, Elisabete Weiderpass, Marc J Gunter, Pietro Ferrari, Heinz Freisling

Department of Public Health - Department of Epidemiology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

8 Citations (Scopus)

Abstract

BACKGROUND: Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear. The primary aim of this study was to evaluate separate and joint associations of BMI and CVD/T2D with the risk of cancer.

METHODS: This is an individual participant data meta-analysis of two prospective cohort studies, the UK Biobank (UKB) and the European Prospective Investigation into Cancer and nutrition (EPIC), with a total of 577,343 adults, free of cancer, T2D, and CVD at recruitment. We used Cox proportional hazard regressions to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between BMI and incidence of obesity-related cancer and in turn overall cancer with a multiplicative interaction between BMI and the two cardiometabolic diseases (CMD). HRs and 95% CIs for separate and joint associations for categories of overweight/obesity and CMD status were estimated, and additive interaction was quantified through relative excess risk due to interaction (RERI).

RESULTS: In the meta-analysis of both cohorts, BMI (per ~ 5 kg/m 2) was positively associated with the risk of obesity-related cancer among participants without a CMD (HR: 1.11, 95%CI: 1.07,1.16), among participants with T2D (HR: 1.11, 95% CI: 1.05,1.18), among participants with CVD (HR: 1.17, 95% CI: 1.11,1.24), and suggestively positive among those with both T2D and CVD (HR: 1.09, 95% CI: 0.94,1.25). An additive interaction between obesity (BMI ≥ 30 kg/m 2) and CVD with the risk of overall cancer translated into a meta-analytical RERI of 0.28 (95% CI: 0.09-0.47).

CONCLUSIONS: Irrespective of CMD status, higher BMI increased the risk of obesity-related cancer among European adults. The additive interaction between obesity and CVD suggests that obesity prevention would translate into a greater cancer risk reduction among population groups with CVD than among the general population.

Original language	English
Article number	418
Journal	BMC Medicine
Volume	21
Issue	1
Number of pages	15
ISSN	1741-7015
DOIs	https://doi.org/10.1186/s12916-023-03114-z
Publication status	Published - Nov 2023

Keywords

Adult
Biological Specimen Banks
Body Mass Index
Cardiovascular Diseases/etiology
Diabetes Mellitus, Type 2/complications
Humans
Multimorbidity
Neoplasms/epidemiology
Obesity
Obesity-related Cancers
Obesity/complications
Prospective Studies
Risk Factors
Type 2 diabetes
United Kingdom/epidemiology

Access to Document

10.1186/s12916-023-03114-zLicence: CC BY

Cite this

Fontvieille, E., Viallon, V., Recalde, M., Cordova, R., Jansana, A., Peruchet-Noray, L., Lennon, H., Heath, A. K., Aune, D., Christakoudi, S., Katzke, V., Kaaks, R., Inan-Eroglu, E., Schulze, M. B., Mellemkjær, L., Tjønneland, A., Overvad, K., Farràs, M., Petrova, D., ... Freisling, H. (2023). Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies. BMC Medicine, 21(1), Article 418. https://doi.org/10.1186/s12916-023-03114-z

@article{7e10426843c0414dab725e4000b54b00,

title = "Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies",

abstract = "BACKGROUND: Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear. The primary aim of this study was to evaluate separate and joint associations of BMI and CVD/T2D with the risk of cancer.METHODS: This is an individual participant data meta-analysis of two prospective cohort studies, the UK Biobank (UKB) and the European Prospective Investigation into Cancer and nutrition (EPIC), with a total of 577,343 adults, free of cancer, T2D, and CVD at recruitment. We used Cox proportional hazard regressions to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between BMI and incidence of obesity-related cancer and in turn overall cancer with a multiplicative interaction between BMI and the two cardiometabolic diseases (CMD). HRs and 95% CIs for separate and joint associations for categories of overweight/obesity and CMD status were estimated, and additive interaction was quantified through relative excess risk due to interaction (RERI).RESULTS: In the meta-analysis of both cohorts, BMI (per ~ 5 kg/m 2) was positively associated with the risk of obesity-related cancer among participants without a CMD (HR: 1.11, 95%CI: 1.07,1.16), among participants with T2D (HR: 1.11, 95% CI: 1.05,1.18), among participants with CVD (HR: 1.17, 95% CI: 1.11,1.24), and suggestively positive among those with both T2D and CVD (HR: 1.09, 95% CI: 0.94,1.25). An additive interaction between obesity (BMI ≥ 30 kg/m 2) and CVD with the risk of overall cancer translated into a meta-analytical RERI of 0.28 (95% CI: 0.09-0.47). CONCLUSIONS: Irrespective of CMD status, higher BMI increased the risk of obesity-related cancer among European adults. The additive interaction between obesity and CVD suggests that obesity prevention would translate into a greater cancer risk reduction among population groups with CVD than among the general population.",

keywords = "Adult, Biological Specimen Banks, Body Mass Index, Cardiovascular Diseases/etiology, Diabetes Mellitus, Type 2/complications, Humans, Multimorbidity, Neoplasms/epidemiology, Obesity, Obesity-related Cancers, Obesity/complications, Prospective Studies, Risk Factors, Type 2 diabetes, United Kingdom/epidemiology",

author = "Emma Fontvieille and Vivian Viallon and Martina Recalde and Reynalda Cordova and Anna Jansana and Laia Peruchet-Noray and Hannah Lennon and Heath, {Alicia K} and Dagfinn Aune and Sofia Christakoudi and Verena Katzke and Rudolf Kaaks and Elif Inan-Eroglu and Schulze, {Matthias B} and Lene Mellemkj{\ae}r and Anne Tj{\o}nneland and Kim Overvad and Marta Farr{\`a}s and Dafina Petrova and Pilar Amiano and Mar{\'i}a-Dolores Chirlaque and Conchi Moreno-Iribas and {Tin Tin}, Sandar and Giovanna Masala and Sabina Sieri and Fulvio Ricceri and Salvatore Panico and May, {Anne M} and Monninkhof, {Evelyn M} and Elisabete Weiderpass and Gunter, {Marc J} and Pietro Ferrari and Heinz Freisling",

year = "2023",

month = nov,

doi = "10.1186/s12916-023-03114-z",

language = "English",

volume = "21",

journal = "BMC Medicine",

issn = "1741-7015",

publisher = "BioMed Central Ltd.",

number = "1",

}

Fontvieille, E, Viallon, V, Recalde, M, Cordova, R, Jansana, A, Peruchet-Noray, L, Lennon, H, Heath, AK, Aune, D, Christakoudi, S, Katzke, V, Kaaks, R, Inan-Eroglu, E, Schulze, MB, Mellemkjær, L, Tjønneland, A, Overvad, K, Farràs, M, Petrova, D, Amiano, P, Chirlaque, M-D, Moreno-Iribas, C, Tin Tin, S, Masala, G, Sieri, S, Ricceri, F, Panico, S, May, AM, Monninkhof, EM, Weiderpass, E, Gunter, MJ, Ferrari, P & Freisling, H 2023, 'Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies', BMC Medicine, vol. 21, no. 1, 418. https://doi.org/10.1186/s12916-023-03114-z

Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies. / Fontvieille, Emma; Viallon, Vivian; Recalde, Martina et al.
In: BMC Medicine, Vol. 21, No. 1, 418, 11.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Body mass index and cancer risk among adults with and without cardiometabolic diseases

T2 - evidence from the EPIC and UK Biobank prospective cohort studies

AU - Fontvieille, Emma

AU - Viallon, Vivian

AU - Recalde, Martina

AU - Cordova, Reynalda

AU - Jansana, Anna

AU - Peruchet-Noray, Laia

AU - Lennon, Hannah

AU - Heath, Alicia K

AU - Aune, Dagfinn

AU - Christakoudi, Sofia

AU - Katzke, Verena

AU - Kaaks, Rudolf

AU - Inan-Eroglu, Elif

AU - Schulze, Matthias B

AU - Mellemkjær, Lene

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Farràs, Marta

AU - Petrova, Dafina

AU - Amiano, Pilar

AU - Chirlaque, María-Dolores

AU - Moreno-Iribas, Conchi

AU - Tin Tin, Sandar

AU - Masala, Giovanna

AU - Sieri, Sabina

AU - Ricceri, Fulvio

AU - Panico, Salvatore

AU - May, Anne M

AU - Monninkhof, Evelyn M

AU - Weiderpass, Elisabete

AU - Gunter, Marc J

AU - Ferrari, Pietro

AU - Freisling, Heinz

PY - 2023/11

Y1 - 2023/11

N2 - BACKGROUND: Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear. The primary aim of this study was to evaluate separate and joint associations of BMI and CVD/T2D with the risk of cancer.METHODS: This is an individual participant data meta-analysis of two prospective cohort studies, the UK Biobank (UKB) and the European Prospective Investigation into Cancer and nutrition (EPIC), with a total of 577,343 adults, free of cancer, T2D, and CVD at recruitment. We used Cox proportional hazard regressions to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between BMI and incidence of obesity-related cancer and in turn overall cancer with a multiplicative interaction between BMI and the two cardiometabolic diseases (CMD). HRs and 95% CIs for separate and joint associations for categories of overweight/obesity and CMD status were estimated, and additive interaction was quantified through relative excess risk due to interaction (RERI).RESULTS: In the meta-analysis of both cohorts, BMI (per ~ 5 kg/m 2) was positively associated with the risk of obesity-related cancer among participants without a CMD (HR: 1.11, 95%CI: 1.07,1.16), among participants with T2D (HR: 1.11, 95% CI: 1.05,1.18), among participants with CVD (HR: 1.17, 95% CI: 1.11,1.24), and suggestively positive among those with both T2D and CVD (HR: 1.09, 95% CI: 0.94,1.25). An additive interaction between obesity (BMI ≥ 30 kg/m 2) and CVD with the risk of overall cancer translated into a meta-analytical RERI of 0.28 (95% CI: 0.09-0.47). CONCLUSIONS: Irrespective of CMD status, higher BMI increased the risk of obesity-related cancer among European adults. The additive interaction between obesity and CVD suggests that obesity prevention would translate into a greater cancer risk reduction among population groups with CVD than among the general population.

AB - BACKGROUND: Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear. The primary aim of this study was to evaluate separate and joint associations of BMI and CVD/T2D with the risk of cancer.METHODS: This is an individual participant data meta-analysis of two prospective cohort studies, the UK Biobank (UKB) and the European Prospective Investigation into Cancer and nutrition (EPIC), with a total of 577,343 adults, free of cancer, T2D, and CVD at recruitment. We used Cox proportional hazard regressions to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between BMI and incidence of obesity-related cancer and in turn overall cancer with a multiplicative interaction between BMI and the two cardiometabolic diseases (CMD). HRs and 95% CIs for separate and joint associations for categories of overweight/obesity and CMD status were estimated, and additive interaction was quantified through relative excess risk due to interaction (RERI).RESULTS: In the meta-analysis of both cohorts, BMI (per ~ 5 kg/m 2) was positively associated with the risk of obesity-related cancer among participants without a CMD (HR: 1.11, 95%CI: 1.07,1.16), among participants with T2D (HR: 1.11, 95% CI: 1.05,1.18), among participants with CVD (HR: 1.17, 95% CI: 1.11,1.24), and suggestively positive among those with both T2D and CVD (HR: 1.09, 95% CI: 0.94,1.25). An additive interaction between obesity (BMI ≥ 30 kg/m 2) and CVD with the risk of overall cancer translated into a meta-analytical RERI of 0.28 (95% CI: 0.09-0.47). CONCLUSIONS: Irrespective of CMD status, higher BMI increased the risk of obesity-related cancer among European adults. The additive interaction between obesity and CVD suggests that obesity prevention would translate into a greater cancer risk reduction among population groups with CVD than among the general population.

KW - Adult

KW - Biological Specimen Banks

KW - Body Mass Index

KW - Cardiovascular Diseases/etiology

KW - Diabetes Mellitus, Type 2/complications

KW - Humans

KW - Multimorbidity

KW - Neoplasms/epidemiology

KW - Obesity

KW - Obesity-related Cancers

KW - Obesity/complications

KW - Prospective Studies

KW - Risk Factors

KW - Type 2 diabetes

KW - United Kingdom/epidemiology

UR - http://www.scopus.com/inward/record.url?scp=85177669887&partnerID=8YFLogxK

U2 - 10.1186/s12916-023-03114-z

DO - 10.1186/s12916-023-03114-z

M3 - Journal article

C2 - 37993940

SN - 1741-7015

VL - 21

JO - BMC Medicine

JF - BMC Medicine

IS - 1

M1 - 418

ER -

Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this