Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

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Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition. / Christakoudi, Sofia; Kakourou, Artemisia; Markozannes, Georgios; Tzoulaki, Ioanna; Weiderpass, Elisabete; Brennan, Paul; Gunter, Marc; Dahm, Christina C; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Madika, Anne-Laure; Severi, Gianluca; Katzke, Verena; Kühn, Tilman; Bergmann, Manuela M; Boeing, Heiner; Karakatsani, Anna; Martimianaki, Georgia; Thriskos, Paschalis; Masala, Giovanna; Sieri, Sabina; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Agudo, Antonio; Redondo-Sánchez, Daniel; Colorado-Yohar, Sandra M; Mokoroa, Olatz; Melander, Olle; Stocks, Tanja; Häggström, Christel; Harlid, Sophia; Bueno-de-Mesquita, Bas; van Gils, Carla H; Vermeulen, Roel C H; Khaw, Kay-Tee; Wareham, Nicholas J; Tong, Tammy Y N; Freisling, Heinz; Johansson, Mattias; Lennon, Hannah; Aune, Dagfinn; Riboli, Elio; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Tsilidis, Konstantinos K.

In: International Journal of Cancer, Vol. 146, No. 10, 15.05.2020, p. 2680-2693.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Christakoudi, S, Kakourou, A, Markozannes, G, Tzoulaki, I, Weiderpass, E, Brennan, P, Gunter, M, Dahm, CC, Overvad, K, Olsen, A, Tjønneland, A, Boutron-Ruault, M-C, Madika, A-L, Severi, G, Katzke, V, Kühn, T, Bergmann, MM, Boeing, H, Karakatsani, A, Martimianaki, G, Thriskos, P, Masala, G, Sieri, S, Panico, S, Tumino, R, Ricceri, F, Agudo, A, Redondo-Sánchez, D, Colorado-Yohar, SM, Mokoroa, O, Melander, O, Stocks, T, Häggström, C, Harlid, S, Bueno-de-Mesquita, B, van Gils, CH, Vermeulen, RCH, Khaw, K-T, Wareham, NJ, Tong, TYN, Freisling, H, Johansson, M, Lennon, H, Aune, D, Riboli, E, Trichopoulos, D, Trichopoulou, A & Tsilidis, KK 2020, 'Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 146, no. 10, pp. 2680-2693. https://doi.org/10.1002/ijc.32576

APA

Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C. C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M-C., Madika, A-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M. M., Boeing, H., Karakatsani, A., ... Tsilidis, K. K. (2020). Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 146(10), 2680-2693. https://doi.org/10.1002/ijc.32576

CBE

Christakoudi S, Kakourou A, Markozannes G, Tzoulaki I, Weiderpass E, Brennan P, Gunter M, Dahm CC, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault M-C, Madika A-L, Severi G, Katzke V, Kühn T, Bergmann MM, Boeing H, Karakatsani A, Martimianaki G, Thriskos P, Masala G, Sieri S, Panico S, Tumino R, Ricceri F, Agudo A, Redondo-Sánchez D, Colorado-Yohar SM, Mokoroa O, Melander O, Stocks T, Häggström C, Harlid S, Bueno-de-Mesquita B, van Gils CH, Vermeulen RCH, Khaw K-T, Wareham NJ, Tong TYN, Freisling H, Johansson M, Lennon H, Aune D, Riboli E, Trichopoulos D, Trichopoulou A, Tsilidis KK. 2020. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 146(10):2680-2693. https://doi.org/10.1002/ijc.32576

MLA

Vancouver

Christakoudi S, Kakourou A, Markozannes G, Tzoulaki I, Weiderpass E, Brennan P et al. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 2020 May 15;146(10):2680-2693. https://doi.org/10.1002/ijc.32576

Author

Christakoudi, Sofia ; Kakourou, Artemisia ; Markozannes, Georgios ; Tzoulaki, Ioanna ; Weiderpass, Elisabete ; Brennan, Paul ; Gunter, Marc ; Dahm, Christina C ; Overvad, Kim ; Olsen, Anja ; Tjønneland, Anne ; Boutron-Ruault, Marie-Christine ; Madika, Anne-Laure ; Severi, Gianluca ; Katzke, Verena ; Kühn, Tilman ; Bergmann, Manuela M ; Boeing, Heiner ; Karakatsani, Anna ; Martimianaki, Georgia ; Thriskos, Paschalis ; Masala, Giovanna ; Sieri, Sabina ; Panico, Salvatore ; Tumino, Rosario ; Ricceri, Fulvio ; Agudo, Antonio ; Redondo-Sánchez, Daniel ; Colorado-Yohar, Sandra M ; Mokoroa, Olatz ; Melander, Olle ; Stocks, Tanja ; Häggström, Christel ; Harlid, Sophia ; Bueno-de-Mesquita, Bas ; van Gils, Carla H ; Vermeulen, Roel C H ; Khaw, Kay-Tee ; Wareham, Nicholas J ; Tong, Tammy Y N ; Freisling, Heinz ; Johansson, Mattias ; Lennon, Hannah ; Aune, Dagfinn ; Riboli, Elio ; Trichopoulos, Dimitrios ; Trichopoulou, Antonia ; Tsilidis, Konstantinos K. / Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition. In: International Journal of Cancer. 2020 ; Vol. 146, No. 10. pp. 2680-2693.

Bibtex

@article{e77a86b5db7f4a1b971f10be1da3fe0d,
title = "Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition",
abstract = "Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08–1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14–1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07–1.26) (SBP), HR = 1.31 (1.13–1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04–1.12) (SBP), HR = 1.09 (1.01–1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82–1.00) and lymphomas: HR = 0.97 (0.93–1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.",
keywords = "Europe, association, cancer, cohort, epidemiology, hypertension, morphology, risk factors, METABOLIC SYNDROME, BODY-SIZE, RENAL-CELL CARCINOMA, ENDOMETRIAL CANCER, BREAST-CANCER, CIGARETTE-SMOKING, THERAPY, COLORECTAL-CANCER, COHORT, INCIDENT HYPERTENSION",
author = "Sofia Christakoudi and Artemisia Kakourou and Georgios Markozannes and Ioanna Tzoulaki and Elisabete Weiderpass and Paul Brennan and Marc Gunter and Dahm, {Christina C} and Kim Overvad and Anja Olsen and Anne Tj{\o}nneland and Marie-Christine Boutron-Ruault and Anne-Laure Madika and Gianluca Severi and Verena Katzke and Tilman K{\"u}hn and Bergmann, {Manuela M} and Heiner Boeing and Anna Karakatsani and Georgia Martimianaki and Paschalis Thriskos and Giovanna Masala and Sabina Sieri and Salvatore Panico and Rosario Tumino and Fulvio Ricceri and Antonio Agudo and Daniel Redondo-S{\'a}nchez and Colorado-Yohar, {Sandra M} and Olatz Mokoroa and Olle Melander and Tanja Stocks and Christel H{\"a}ggstr{\"o}m and Sophia Harlid and Bas Bueno-de-Mesquita and {van Gils}, {Carla H} and Vermeulen, {Roel C H} and Kay-Tee Khaw and Wareham, {Nicholas J} and Tong, {Tammy Y N} and Heinz Freisling and Mattias Johansson and Hannah Lennon and Dagfinn Aune and Elio Riboli and Dimitrios Trichopoulos and Antonia Trichopoulou and Tsilidis, {Konstantinos K}",
note = "This article is protected by copyright. All rights reserved.",
year = "2020",
month = may,
day = "15",
doi = "10.1002/ijc.32576",
language = "English",
volume = "146",
pages = "2680--2693",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "JohnWiley & Sons, Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

AU - Christakoudi, Sofia

AU - Kakourou, Artemisia

AU - Markozannes, Georgios

AU - Tzoulaki, Ioanna

AU - Weiderpass, Elisabete

AU - Brennan, Paul

AU - Gunter, Marc

AU - Dahm, Christina C

AU - Overvad, Kim

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Boutron-Ruault, Marie-Christine

AU - Madika, Anne-Laure

AU - Severi, Gianluca

AU - Katzke, Verena

AU - Kühn, Tilman

AU - Bergmann, Manuela M

AU - Boeing, Heiner

AU - Karakatsani, Anna

AU - Martimianaki, Georgia

AU - Thriskos, Paschalis

AU - Masala, Giovanna

AU - Sieri, Sabina

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Agudo, Antonio

AU - Redondo-Sánchez, Daniel

AU - Colorado-Yohar, Sandra M

AU - Mokoroa, Olatz

AU - Melander, Olle

AU - Stocks, Tanja

AU - Häggström, Christel

AU - Harlid, Sophia

AU - Bueno-de-Mesquita, Bas

AU - van Gils, Carla H

AU - Vermeulen, Roel C H

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas J

AU - Tong, Tammy Y N

AU - Freisling, Heinz

AU - Johansson, Mattias

AU - Lennon, Hannah

AU - Aune, Dagfinn

AU - Riboli, Elio

AU - Trichopoulos, Dimitrios

AU - Trichopoulou, Antonia

AU - Tsilidis, Konstantinos K

N1 - This article is protected by copyright. All rights reserved.

PY - 2020/5/15

Y1 - 2020/5/15

N2 - Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08–1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14–1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07–1.26) (SBP), HR = 1.31 (1.13–1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04–1.12) (SBP), HR = 1.09 (1.01–1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82–1.00) and lymphomas: HR = 0.97 (0.93–1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.

AB - Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08–1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14–1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07–1.26) (SBP), HR = 1.31 (1.13–1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04–1.12) (SBP), HR = 1.09 (1.01–1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82–1.00) and lymphomas: HR = 0.97 (0.93–1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.

KW - Europe

KW - association

KW - cancer

KW - cohort

KW - epidemiology

KW - hypertension

KW - morphology

KW - risk factors

KW - METABOLIC SYNDROME

KW - BODY-SIZE

KW - RENAL-CELL CARCINOMA

KW - ENDOMETRIAL CANCER

KW - BREAST-CANCER

KW - CIGARETTE-SMOKING

KW - THERAPY

KW - COLORECTAL-CANCER

KW - COHORT

KW - INCIDENT HYPERTENSION

UR - http://www.scopus.com/inward/record.url?scp=85071268694&partnerID=8YFLogxK

U2 - 10.1002/ijc.32576

DO - 10.1002/ijc.32576

M3 - Journal article

C2 - 31319002

VL - 146

SP - 2680

EP - 2693

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 10

ER -