Biomimetic fabrication of dynamic biointerfaces with optional and diversified bioactivities through reversible covalent and bioorthogonal chemistry

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Biomimetic fabrication of dynamic biointerfaces with optional and diversified bioactivities through reversible covalent and bioorthogonal chemistry. / Tian, Xiaohua; Chen, Xu; Feng, Yonghai; Duan, Yuqing; Dong, Mingdong; Pan, Guoqing; Liu, Lei.

In: Chemical Engineering Journal, Vol. 398, 125620, 10.2020.

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Tian, Xiaohua ; Chen, Xu ; Feng, Yonghai ; Duan, Yuqing ; Dong, Mingdong ; Pan, Guoqing ; Liu, Lei. / Biomimetic fabrication of dynamic biointerfaces with optional and diversified bioactivities through reversible covalent and bioorthogonal chemistry. In: Chemical Engineering Journal. 2020 ; Vol. 398.

Bibtex

@article{0c405f4a718a4f0e91b606714189f2c0,
title = "Biomimetic fabrication of dynamic biointerfaces with optional and diversified bioactivities through reversible covalent and bioorthogonal chemistry",
abstract = "As extracellular matrix (ECM) mimics, dynamic biointerfaces with reversible ligand presentation have shown great significance in the field of biology and medicine. However, current systems are trapped in the monotony of bioactivity, which makes it hard to mimic the multipotential of natural ECM. In this work, we reported a dynamic biomaterial interface with optional and diversified bioactivities by the combination of reversible catechol-boronate and bioorthogonal click chemistry. Due to the specificity and thoroughness of bioorthogonal reaction, different types of biomolecules including small molecular saccharide, macromolecular peptides and DNA aptamers could be on-demand and reversible binding on biomaterial interfaces through sugar-sensitive catechol-boronate interactions. In this design, the obtained dynamic biointerface showed biocompatible sugar-responsiveness and enabled reversible presentation of diversified bioactivities, exhibiting the multipotential to manipulate a variety of cell-biomaterial interactions. Cell capture/release experiments confirmed our dynamic biointerface could reversibly and selectively bind different cancer cells and even the bacterial microorganism. In short, apart from the original significance in ECM mimicking, the optional and diversified bioactivities on our developed dynamic biointerface will also show promising prospects in biomedical science, in particular, the cell isolation area for diagnostics and therapeutics.",
keywords = "Bacteria, Cells capture and release, Click chemistry, Dynamic biointerface, Mussel-inspired peptide",
author = "Xiaohua Tian and Xu Chen and Yonghai Feng and Yuqing Duan and Mingdong Dong and Guoqing Pan and Lei Liu",
year = "2020",
month = oct,
doi = "10.1016/j.cej.2020.125620",
language = "English",
volume = "398",
journal = "Chemical Engineering Journal",
issn = "1385-8947",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Biomimetic fabrication of dynamic biointerfaces with optional and diversified bioactivities through reversible covalent and bioorthogonal chemistry

AU - Tian, Xiaohua

AU - Chen, Xu

AU - Feng, Yonghai

AU - Duan, Yuqing

AU - Dong, Mingdong

AU - Pan, Guoqing

AU - Liu, Lei

PY - 2020/10

Y1 - 2020/10

N2 - As extracellular matrix (ECM) mimics, dynamic biointerfaces with reversible ligand presentation have shown great significance in the field of biology and medicine. However, current systems are trapped in the monotony of bioactivity, which makes it hard to mimic the multipotential of natural ECM. In this work, we reported a dynamic biomaterial interface with optional and diversified bioactivities by the combination of reversible catechol-boronate and bioorthogonal click chemistry. Due to the specificity and thoroughness of bioorthogonal reaction, different types of biomolecules including small molecular saccharide, macromolecular peptides and DNA aptamers could be on-demand and reversible binding on biomaterial interfaces through sugar-sensitive catechol-boronate interactions. In this design, the obtained dynamic biointerface showed biocompatible sugar-responsiveness and enabled reversible presentation of diversified bioactivities, exhibiting the multipotential to manipulate a variety of cell-biomaterial interactions. Cell capture/release experiments confirmed our dynamic biointerface could reversibly and selectively bind different cancer cells and even the bacterial microorganism. In short, apart from the original significance in ECM mimicking, the optional and diversified bioactivities on our developed dynamic biointerface will also show promising prospects in biomedical science, in particular, the cell isolation area for diagnostics and therapeutics.

AB - As extracellular matrix (ECM) mimics, dynamic biointerfaces with reversible ligand presentation have shown great significance in the field of biology and medicine. However, current systems are trapped in the monotony of bioactivity, which makes it hard to mimic the multipotential of natural ECM. In this work, we reported a dynamic biomaterial interface with optional and diversified bioactivities by the combination of reversible catechol-boronate and bioorthogonal click chemistry. Due to the specificity and thoroughness of bioorthogonal reaction, different types of biomolecules including small molecular saccharide, macromolecular peptides and DNA aptamers could be on-demand and reversible binding on biomaterial interfaces through sugar-sensitive catechol-boronate interactions. In this design, the obtained dynamic biointerface showed biocompatible sugar-responsiveness and enabled reversible presentation of diversified bioactivities, exhibiting the multipotential to manipulate a variety of cell-biomaterial interactions. Cell capture/release experiments confirmed our dynamic biointerface could reversibly and selectively bind different cancer cells and even the bacterial microorganism. In short, apart from the original significance in ECM mimicking, the optional and diversified bioactivities on our developed dynamic biointerface will also show promising prospects in biomedical science, in particular, the cell isolation area for diagnostics and therapeutics.

KW - Bacteria

KW - Cells capture and release

KW - Click chemistry

KW - Dynamic biointerface

KW - Mussel-inspired peptide

UR - http://www.scopus.com/inward/record.url?scp=85085350366&partnerID=8YFLogxK

U2 - 10.1016/j.cej.2020.125620

DO - 10.1016/j.cej.2020.125620

M3 - Journal article

AN - SCOPUS:85085350366

VL - 398

JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

SN - 1385-8947

M1 - 125620

ER -