Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic Syndrome

Steven Brantlov, Lars Jødal, René Frydensbjerg Andersen, Aksel Lange, Søren Rittig, Leigh C Ward

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Background: Accumulation of extracellular water (ECW) is a major clinical manifestation of nephrotic syndrome (NS) in children. Bioimpedance spectroscopy (BIS) is a simple, noninvasive technique that reflects body water volumes. BIS can further measure cell membrane capacitance (CM), which may be altered in NS. The aims of the study were to explore how BIS measurements could reflect disease status in NS, while avoiding prediction equations which are often only validated in adult populations.

Methods: The study involved 8 children (2-10 years) with active NS (ANS group), 5 of which were also studied at NS remission (NSR group), as well as 38 healthy children of similar age (HC group). BIS measurements determined resistances RINF, RE, and RI (reflecting total body water, extracellular water, and intracellular water) and CM. Also resistance indices based on height (H) were considered, RI = H2/R.

Results: It was found that RE and RINF were significantly lower in the ANS group than in both NSR and HC groups (p < 0.001). Corresponding resistance indices were significantly higher in the ANS group than in the NSR (p < 0.01) and the HC (p < 0.05) groups, in accordance with elevated water volumes in NS patients. Indices of intracellular water were not significantly different between groups. CM was significantly lower in the ANS group than in NSR and HC groups (p < 0.05).

Conclusion: BIS could distinguish children with active NS from well-treated and healthy children. Studies with more children are warranted.

Original languageEnglish
Article number4274856
JournalScientific World Journal
Volume2019
ISSN2356-6140
DOIs
Publication statusPublished - 2019

Keywords

  • Anthropometry
  • Biomarkers
  • Case-Control Studies
  • Cell Membrane/metabolism
  • Child
  • Child, Preschool
  • Electric Impedance
  • Electrophysiological Phenomena
  • Female
  • Humans
  • Male
  • Nephrotic Syndrome/diagnosis
  • Severity of Illness Index
  • Spectrum Analysis

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