Binding of chemical carcinogens to macromolecules in cultured human colon.

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DOI

https://doi.org/10.1093/jnci/59.2.351
Final published version

Herman Autrup
C.C. Harris, United States
G.D. Stoner, United States
M.L. Jesudason, United States
B.F. Trump, United States

Institute of Environmental and Occupational Medicine

Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo(a)pyrene, dimethylnitrosamine, and 1,2-
dimethylhydrazine was found in both cell DNA and protein. 1,2-Dimethylhydrazine methylated DNA at both N·7 and 0-6 positions of guanin.

Original language	English
Journal	National Cancer Institute. Journal (Print)
Volume	59
Issue	2
Pages (from-to)	351-354
Number of pages	4
ISSN	0027-8874
DOIs	https://doi.org/10.1093/jnci/59.2.351
Publication status	Published - 1977

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