Binding of chemical carcinogens to macromolecules in cultured human colon.

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  • Herman Autrup, Human Tissue Studies Section, Experimental Pathology Branch, Division of Cancer Cause and Prevention, NCI, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, Denmark
  • C.C. Harris, United States
  • G.D. Stoner, United States
  • M.L. Jesudason, United States
  • B.F. Trump, United States
  • Institute of Environmental and Occupational Medicine
Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo(a)pyrene, dimethylnitrosamine, and 1,2-
dimethylhydrazine was found in both cell DNA and protein. 1,2-Dimethylhydrazine methylated DNA at both N·7 and 0-6 positions of guanin.
Original languageEnglish
JournalNational Cancer Institute. Journal (Print)
Pages (from-to)351-354
Number of pages4
Publication statusPublished - 1977

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