Binding of chemical carcinogens to macromolecules in cultured human colon.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperLetterResearchpeer-review

DOI

  • Herman Autrup
  • C.C. Harris, United States
  • G.D. Stoner, United States
  • M.L. Jesudason, United States
  • B.F. Trump, United States
  • Institute of Environmental and Occupational Medicine
Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo(a)pyrene, dimethylnitrosamine, and 1,2-
dimethylhydrazine was found in both cell DNA and protein. 1,2-Dimethylhydrazine methylated DNA at both N·7 and 0-6 positions of guanin.
Original languageEnglish
JournalNational Cancer Institute. Journal (Print)
Volume59
Issue2
Pages (from-to)351-354
Number of pages4
ISSN0027-8874
DOIs
Publication statusPublished - 1977

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