Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Patrik Brundin, Lunds Universitet
  • ,
  • Oliver Pogarell, Klinikum Grosshaden, Philipps-Universität Marburg
  • ,
  • Peter Hagell, Lund University Hospital
  • ,
  • Paola Piccini, Hammersmith Hospital
  • ,
  • Håkan Widner, Lund University Hospital, Lunds Universitet
  • ,
  • Anette Schrag, Natl. Hosp. Neurol. and Neurosurg.
  • ,
  • Andreas Kupsch, Klinikum Grosshaden
  • ,
  • Lesley Crabb, Natl. Hosp. Neurol. and Neurosurg.
  • ,
  • Per Odin, Lund University Hospital
  • ,
  • Björn Gustavii, Lund University Hospital
  • ,
  • Anders Björklund, Lunds Universitet
  • ,
  • David J. Brooks
  • C. David Marsden, Natl. Hosp. Neurol. and Neurosurg.
  • ,
  • Wolfgang H. Oertel, Klinikum Grosshaden, Philipps-Universität Marburg
  • ,
  • Niall P. Quinn, Natl. Hosp. Neurol. and Neurosurg.
  • ,
  • Stig Rehncrona, Lund University Hospital
  • ,
  • Olle Lindvall, Lund University Hospital

Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic tissue from between seven and nine donors. To increase graft survival, the lipid peroxidation inhibitor tirilazad mesylate was administered to the tissue before implantation and intravenously to the patients for 3 days thereafter. During the second postoperative year, the mean daily L-dopa dose was reduced by 54% and the UPDRS (Unified Parkinson's Disease Rating Scale) motor score in 'off' phase was reduced by a mean of 40%. At 10-23 months after grafting, PET showed a mean 61% increase of 6-L-[18F]fluorodopa uptake in the putamen, and 24% increase in the caudate nucleus, compared with preoperative values. No obvious differences in the pattern of motor recovery were observed between these and other previously studied cases with putamen grafts alone. The amount of mesencephalic tissue implanted in each putamen and caudate nucleus was 42 and 50% lower, respectively, compared with previously transplanted patients from our centre. Despite this reduction in grafted tissue, the magnitudes of symptomatic relief and graft survival were very similar. These findings suggest that tirilazad mesylate may improve survival of grafted dopamine neurons in patients, which is in agreement with observations in experimental animals.

Original languageEnglish
JournalBrain
Volume123
Issue7
Pages (from-to)1380-1390
Number of pages11
ISSN0006-8950
Publication statusPublished - 1 Jul 2000
Externally publishedYes

    Research areas

  • Dopamine, Lazaroid, Neural transplantation, Parkinson's disease, Positron emission tomography

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