Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders

Seyedeh Marziyeh Jabbari Shiadeh; Wing Ki Chan; Sofia Rasmusson; Noor Hassan; Sâmia Joca; Lars Westberg; Anders Elfvin; Carina Mallard; Maryam Ardalan

doi:10.1038/s41398-025-03504-2

Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders

Seyedeh Marziyeh Jabbari Shiadeh
, Wing Ki Chan
, Sofia Rasmusson
, Noor Hassan
, Sâmia Joca
, Lars Westberg
, Anders Elfvin
, Carina Mallard
, Maryam Ardalan^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

2 Citations (Scopus)

Abstract

The gut-brain axis serves as a crucial communication pathway, with microbial metabolites such as short-chain fatty acids (SCFAs) playing a central role in regulating neuroinflammation and maintaining neuronal health. The gut microbiota’s impact on neurodevelopment is highlighted, particularly its relevance to autism, anxiety, and other psychiatric conditions. In this review, we explored the intricate relationship between the gut microbiota (GM) and the central nervous system (CNS), emphasizing the bidirectional communication that forms the gut-brain axis. Associations between specific gut microbiota and neurodegenerative diseases are explored, focusing on the role of certain bacteria in processes such as amyloid aggregation and neuroinflammation in Alzheimer’s disease (AD) and Parkinson’s disease (PD). The potential for therapeutic modulation of the gut microbiota is discussed, with a focus on dietary interventions and probiotics as strategies to improve outcomes in neurodegenerative diseases by restoring gut health. We concluded by emphasizing the significance of understanding the gut-brain connection and calls for further research to investigate therapeutic approaches targeting the gut microbiome for brain health.

Original language	English
Article number	278
Journal	Translational Psychiatry
Volume	15
Issue	1
ISSN	2158-3188
DOIs	https://doi.org/10.1038/s41398-025-03504-2
Publication status	Published - Dec 2025

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Jabbari Shiadeh, S. M., Chan, W. K., Rasmusson, S., Hassan, N., Joca, S., Westberg, L., Elfvin, A., Mallard, C., & Ardalan, M. (2025). Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders. Translational Psychiatry, 15(1), Article 278. https://doi.org/10.1038/s41398-025-03504-2

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abstract = "The gut-brain axis serves as a crucial communication pathway, with microbial metabolites such as short-chain fatty acids (SCFAs) playing a central role in regulating neuroinflammation and maintaining neuronal health. The gut microbiota{\textquoteright}s impact on neurodevelopment is highlighted, particularly its relevance to autism, anxiety, and other psychiatric conditions. In this review, we explored the intricate relationship between the gut microbiota (GM) and the central nervous system (CNS), emphasizing the bidirectional communication that forms the gut-brain axis. Associations between specific gut microbiota and neurodegenerative diseases are explored, focusing on the role of certain bacteria in processes such as amyloid aggregation and neuroinflammation in Alzheimer{\textquoteright}s disease (AD) and Parkinson{\textquoteright}s disease (PD). The potential for therapeutic modulation of the gut microbiota is discussed, with a focus on dietary interventions and probiotics as strategies to improve outcomes in neurodegenerative diseases by restoring gut health. We concluded by emphasizing the significance of understanding the gut-brain connection and calls for further research to investigate therapeutic approaches targeting the gut microbiome for brain health.",

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Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders. / Jabbari Shiadeh, Seyedeh Marziyeh; Chan, Wing Ki; Rasmusson, Sofia et al.
In: Translational Psychiatry, Vol. 15, No. 1, 278, 12.2025.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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T2 - Implications for neurodevelopmental and neuropsychiatric disorders

AU - Jabbari Shiadeh, Seyedeh Marziyeh

AU - Chan, Wing Ki

AU - Rasmusson, Sofia

AU - Hassan, Noor

AU - Joca, Sâmia

AU - Westberg, Lars

AU - Elfvin, Anders

AU - Mallard, Carina

AU - Ardalan, Maryam

PY - 2025/12

Y1 - 2025/12

N2 - The gut-brain axis serves as a crucial communication pathway, with microbial metabolites such as short-chain fatty acids (SCFAs) playing a central role in regulating neuroinflammation and maintaining neuronal health. The gut microbiota’s impact on neurodevelopment is highlighted, particularly its relevance to autism, anxiety, and other psychiatric conditions. In this review, we explored the intricate relationship between the gut microbiota (GM) and the central nervous system (CNS), emphasizing the bidirectional communication that forms the gut-brain axis. Associations between specific gut microbiota and neurodegenerative diseases are explored, focusing on the role of certain bacteria in processes such as amyloid aggregation and neuroinflammation in Alzheimer’s disease (AD) and Parkinson’s disease (PD). The potential for therapeutic modulation of the gut microbiota is discussed, with a focus on dietary interventions and probiotics as strategies to improve outcomes in neurodegenerative diseases by restoring gut health. We concluded by emphasizing the significance of understanding the gut-brain connection and calls for further research to investigate therapeutic approaches targeting the gut microbiome for brain health.

AB - The gut-brain axis serves as a crucial communication pathway, with microbial metabolites such as short-chain fatty acids (SCFAs) playing a central role in regulating neuroinflammation and maintaining neuronal health. The gut microbiota’s impact on neurodevelopment is highlighted, particularly its relevance to autism, anxiety, and other psychiatric conditions. In this review, we explored the intricate relationship between the gut microbiota (GM) and the central nervous system (CNS), emphasizing the bidirectional communication that forms the gut-brain axis. Associations between specific gut microbiota and neurodegenerative diseases are explored, focusing on the role of certain bacteria in processes such as amyloid aggregation and neuroinflammation in Alzheimer’s disease (AD) and Parkinson’s disease (PD). The potential for therapeutic modulation of the gut microbiota is discussed, with a focus on dietary interventions and probiotics as strategies to improve outcomes in neurodegenerative diseases by restoring gut health. We concluded by emphasizing the significance of understanding the gut-brain connection and calls for further research to investigate therapeutic approaches targeting the gut microbiome for brain health.

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Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders

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